摘要
目的探讨应用COBE Spectra血细胞分离机进行红细胞单采术辅助治疗真性红细胞增多症的疗效。方法应用COBE Spectra血细胞分离机对18例真性红细胞增多症进行红细胞单采术,共27次,单采后接受羟基脲口服;同时与32例单用羟基脲的真性红细胞增多症患者进行对比,观察疗效的时间为1个月。结果①在单采联合羟基脲治疗组,18例患者血红蛋白中位数210(179～261)g/L下降至165(155～220)g/L,颜面绛紫色好转,血压下降,与术前比较差异有统计学意义(P<0.01);②32例单用羟基脲的真性红细胞性增多症患者血红蛋白中位数209.5(158～242)g/L下降至183.5(124～228)g/L,颜面绛紫色有所好转,与用药前相比有统计学意义(P<0.01);③单采联合羟基脲组血红蛋白降低更加明显,每次单采后血红蛋白即刻下降,且血红蛋白下降的中位天数(10天)明显少于单用羟基脲组(4天),有统计学意义(P<0.05)。结论利用血细胞分离机进行红细胞单采术,其临床效果肯定,能迅速缓解症状,优于单用羟基脲治疗,且安全、可靠、不良反应小。
Objective To explore curative effect of haemocyte pheresis in treatment of polycy- themia vera using COBE Spectra, haemocyte separator. Method Hemocyte pheresis was un- dertaken in 18 patients with haemocyte pheresis using COBE Spectra, haemocyte separator, fol- lowing the treatment with hydroxycarhamide. Thirty-two patients with polyeythemia vera who were treated with hydroxycarbamide only were analyzed for comparison. The efficacy was ob- served for 1 mouth. Results In the group of haemocyte pheresis and hydroxycarbamide, he- moglobin decreased from 210 g/L to 165 g/L, and facial color was improved, blood pressure descend, which had statistical signifieances compared with pre-operation （P 〈 0. 01 ）. Hemo- globin of 32 patients treated with hydroxycarbamide decreased from 209.5 （ 158 - 242 ） g/L to 183.5 （ 124 - 228 ） g/L. Dark reddish purple got better to some extent. Statistical significance was seen compared with pre-treatment （P 〈0.01 ）. The decrease in hemoglobin was even more obvious in haemocyte pheresis group （P 〈 0. 05 ）. Conclusion Hemocyte pheresis using COBE Spectra is a safe and effective method with less adverse reaction, and better than hydroxycarbamide only.
出处
《哈尔滨医科大学学报》
CAS
北大核心
2013年第2期189-190,196,共3页
Journal of Harbin Medical University
