摘要
目的 :研究前列安栓在大鼠体内的吸收及分布 ,探讨中药复方药代动力学研究的方法 ,并为该药在临床上的合理使用提供依据。 方法 :雄性大鼠直肠给药 ,剂量为 5g生药 (2 0 0 μCi) /kg,于规定时间分批取血、前列腺、直肠及相关脏器测定放射性。 结果 :药后 5min即可从血液中测到放射性 ,血液药 时曲线符合开放型二室模型 ;药后 5min从靶器官 (前列腺 )中也测到放射性 ,药物放射性在前列腺中的富集浓度高于其它器官 (直肠、肝、肾除外 ) ,至 2 4h仍维持一定水平 ;除直肠外 ,药物放射性在肝、肾中的水平最高。 结论 :该药自直肠吸收迅速 ,并迅速到达靶器官 (前列腺 ) ,易于前列腺中富集 ,这对前列腺炎及前列腺增生的治疗有特殊意义 ;肝。
WT5”HX]Objectives:[WT5”BZ]To study absorption and distribution of Qianlie Anshuan in rats, probe into the method in studying pharmacokinetics of compound recipes of Chinese materia medica, and provide an experiment evidence for the rational uses of Qianlie Anshan in clinic. [WT5”HX] Methods: [WT5”BZ]After Qianlie Anshuan was administered to male rats via rectum at crude drug 5g(200 μ Ci)/kg, the radioactivity in blood, prostate, rectum and related organs was detected at prescript time. [WT5”HX]Results:[WT5”BZ]Radioactivity was found in blood at 5 minute after administration. The blood concentration time curve was shown to fit a two compartment open model. Radioactivity was also found in target organ (prostate) at 5 minute after administration. Radioactivity was found to be higher in prostate than in any other organs except rectum, liver and kidney. Radioactivity in prostate remains a certain level at 24h after administration. Next to rectum, the radioactivity in liver and kidney was the highest. [WT5”HX] Conclusions: [WT5”BZ]After administration via rectum, Qianlie Anshuan was absorbed rapidly, and distributed rapidly to target organ(prostate). Higher concentration of the drug in prostate is especially helpful for therapies of prostatitis and hyperplasia of prostate. Liver and kidney seemed to be the main routes of metabolism and excretion of the drug. [WT5”HZ]
出处
《中华男科学杂志》
CAS
CSCD
2000年第2期107-110,共4页
National Journal of Andrology
关键词
前列安栓
吸收
分布
药代动力学
药理
WT5”BZ]Qianlie Anshuan
Absorption
Distribution
Pharmacokinetics
