摘要
总结了人绒毛膜促性腺激素 (hCG)避孕疫苗的开发研究。这类疫苗能阻止性活跃妇女受孕而不损害排卵 ,也不扰乱月经规律。同时还总结了有关诱导针对黄体释放激素抗体的疫苗研究 ,以及这类疫苗在包括前列腺肥大和其它性激素相关的男女癌症的免疫治疗方面的应用。主张应用人源性重组抗激素抗体的被动免疫方法来保证有效、安全。
WT5”BZ]This article summarizes the development of a vaccine against the human chorionic gonadotropin that prevents pregnancy in sexually active women without impairment of ovulation or derangement of menstrual regularity. Also summarized are the vaccines inducing antibodies aginst the luteinizing hormone releasing hormone, which have immunotherapeutic potential in prostatic hypertrophy and other sex hormone dependent male and female cancers. The adoption of passive immunization using humanized recombinant anti hormone antibodies is advocated for assured efficacy and safe, prompt therapeutic action. (With the Chinese translation by Nian Qing LU) [WT5”HZ]
出处
《中华男科学杂志》
CAS
CSCD
2000年第2期77-88,共12页
National Journal of Andrology
基金
CurrentworkofG .P .TalwarissupportedbyresearchgrantsfromtheRockefellerFoundationandtheTalwarResearchFoundation .
关键词
生育
激素依赖性癌症
疫苗
被动免疫
WT5”BZ]Fertility regulation
Human chorionic gonadotropin (hCG)
Vaccine
Luteinizing hormone releasing hormone
Prostatic hypertrophy
Passive immunization
Therapy
