摘要
目的 观察α-硫辛酸、莫沙必利联合治疗糖尿病神经源性膀胱的临床疗效。方法 30例2型糖尿病神经源性膀胱患者,在良好控制血糖、血脂等代谢指标的基础上,给α-硫辛酸、莫沙必利联合治疗3周,比较治疗前后膀胱残余尿量及尿动力学指标的变化。结果 治疗3周及停药4周后患者膀胱残余尿量、平均尿流率、最大尿流率、逼尿肌压力分别为（62.5±27.8）ml和（61.3±21.6）ml、（8.3±1.9）ml/s和（7.9±2.1）ml/s、（10.7±1.8）ml/s和（10.3±1.6）ml/s、（25.6±2.7）cm H2O和（24.5±2.3）cm H2O,均优于治疗前的（128.3±72.5）ml、（5.2±1.3）ml/s、（8.4±1.2）ml/s、（18.1±1.2）cm H2O（t=4.01、4.21、3.45、3.52、3.68、3.47、3.33、3.24,均P〈0.01）。结论 α-硫辛酸联合莫沙必利治疗糖尿病神经源性膀胱有较好的临床疗效。
Objective To observe the efficacy of lipoic acid combined with mosapride in the treatment of diabetic neurogenic bladder.Methods 30 patients with type 2 diabetes complicated with diabatic neurogenic bladder were treated with lipoic acid and mosapride for three weeks,on the base of good controlling of blood glucose,blood lipids,and other metabolic indicators.The residual urine volume of bladder and urodynamic indicators were compared before and after treatment.Results The residual urine volume of bladder and urodynamic indicators after treatment for three weeks and withdrawal for four weeks were （62.5±27.8）ml and （61.3±21.6）ml,（8.3±1.9）ml/s and （7.9±2.1）ml/s,（10.7±1.8）ml/s and （10.3±1.6）ml/s,（25.6±2.7）cm H2O and （24.5±2.3）cm H2O,which were significiantly better than those before treatment[（128.3±72.5）ml,（5.2±1.3）ml/s,（8.4±1.2）ml/s,（18.1±1.2）cm H2O]（t=4.01,4.21,3.45,3.52,3.68,3.47,3.33,3.24,all P〈0.01）.Conclusion Lipoic acid combined with mosapride has good effect in the treatment of diabetic neurogenic bladder.
出处
《中国基层医药》
CAS
2013年第11期1620-1621,共2页
Chinese Journal of Primary Medicine and Pharmacy
