摘要
目的探讨抗结核板式组合药物不良反应发生影响因素。方法对2011-2012年淮安地区网络直报的707例活动性肺结核患者提供抗结核板式组合药物治疗,记录患者相关特征及不良反应发生情况。结果板式组合药物不良反应发生率为32.96%,单因素分析显示,患者不同年龄、文化程度、服药方式、有无肝炎病史、是否营养不良的ADR发生率差异有统计学意义(P<0.05);多因素非条件logistic回归结果表明年龄越大、文化程度越低、有肝炎病史的患者服用板式组合药发生ADR的危险性较大。结论高龄、肝炎病史是抗结核板式组合药物不良反应发生的危险因素,文化程度是保护因素。
Objective To investigate the incidence and influence factors of plate combination anti-tuberculosis（anti-TB） drugs-induced adverse reactions. Methods A total of 707 patients with active pulmonary tuberculosis were remedied by taking plate combination anti-TB drugs during 2001--2012 in Huaian. The patients＇ personal information and adverse-drug-reactions （ADR） were recorded. Results It was shown that the plate combination anti-TB drugs induced ADR incident was 32.96%. A single factor analysis showed that patients with different ages, educational backgruoud, doses of tablets, hepatitis history and malnutrition were all associated with ADR incidence with statistical meaningfulness（P〈0.05）. Moreover, multivariate non- conditional logistic regression analysis found that elder ages, lower educational levels and had hepatitis history in patients had grater risks for ADR incidence. Conelusion Elder ages and hepatitis history are the risk factors of ADR, while educational level is the protective factor.
出处
《江苏预防医学》
CAS
2013年第3期11-12,共2页
Jiangsu Journal of Preventive Medicine
基金
江苏省预防医学科研课题(YZ201005)
关键词
抗结核板式组合药
不良反应
影响因素
肺结核
plate combination anti-tuberculosis drugs
adverse drug reaction
influence factors
pulmonary tuberculosis
