摘要
目的观察短期胰岛素泵强化治疗难治性2型糖尿病的治疗效果。方法选取难治性2型糖尿病患者50例,给予胰岛素泵强化治疗5d,其中20例联合持续动态血糖监测系统(CGMS)。观察患者治疗前后胰岛素总量,空腹及3餐后2h血糖,比较患者用泵起始、结束时平均血糖(MBG),血糖的曲线下面积(AUC)。结果胰岛素泵强化治疗可在相对短的时间内控制好空腹血糖、餐后血糖(P<0.01),且胰岛素的使用总量与治疗前比较无明显差异(P>0.05),联合CGMS治疗的患者用泵起始、结束时MBG,血糖的AUC均存在显著性差异(P<0.01)。结论短期胰岛素泵强化治疗难治性糖尿病效果好,胰岛素总量未增加。联合CGMS能监测血糖连续的变化曲线,可及时发现高血糖和低血糖,血糖波动小。
Objective To investigate the therapeutic outcomes of continuous subcutaneous insulin infusion pump system in type 2 diabetes mellitus（T2DM） patients with refractory hyperglycemia patients.Methods A total of 50 T2DM patients with refractory hyperglycemia were treated in CSII,continuous glucose monitoring system（CGMS）combined with CSII in 20 cases.The capillary blood glucose of finger tip was monitored in all patients.The changes of fasting blood glucose（FBG）,2 hours blood glucose values（2hBG）,the mean blood glucose（MBG）,glucose area under curve（AUC） and the total use of insulin were recorded and compared among all patients before and after treatment for 5 days.Results After pump therapy for 5 days,the whole day glucose,MBG and AUC were all significantly lower after treatment than those before treatment（P0.01）.However the total use of insulin were not obviously different compared with that before treatment（P0.05）.Conclusions Short term insulin pump intensive therapy is more beneficial to the glucose control in refractory T2DM without increasing total amount of insulin.Combined with CGMS it can depict a contin uous blood glucose curve,monitoring hyperglycemia or hypoglycemia events and minimize blood glucose fluctuations
出处
《中华保健医学杂志》
2013年第2期131-133,共3页
Chinese Journal of Health Care and Medicine
关键词
胰岛素泵
大剂量胰岛素
糖尿病
continuous subcutaneous Insulin infusion pump
large dose insulin
diabetes mellitus
