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大剂量甲基强的松龙联合人免疫球蛋白治疗60例重症手足口病合并脑炎效果观察 被引量:14

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摘要 目的探讨静脉滴注冲击量甲强龙联合人免疫球蛋白治疗小儿手足口病重症合并脑炎的效果。方法总结分析2012年3月~2012年6月于本院治疗的手足口病重症合并脑炎患者60例,将60例手足口病重症患儿随机分为观察组42例和对照组18例,两组均行抗炎、抗病毒及对症支持治疗,观察组静脉滴注冲击量甲强龙(10~20mg·kg-1)联合静脉滴注入大剂量免疫球蛋白(1~2g·kg-1)以达到抗炎、促进肺水肿吸收、防治脑水肿、增强免疫的目的 ;对照组给予小剂量甲强龙及小剂量免疫球蛋白静脉滴注。结果观察组患儿热退、皮疹消失、神经系统症状缓解时间均小于对照组,两组比较差异有统计学意义(P<0.05)。结论手足口病重症合并脑炎患者早期明确诊断、积极对症治疗,早期给予大剂量激素和人免疫球蛋白阻止患儿病情进展为心血管衰竭期,预后良好。
作者 范林祥
出处 《海峡药学》 2013年第4期74-75,共2页 Strait Pharmaceutical Journal
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