摘要
目的评价4种不同用药方案治疗社区2型糖尿病的经济学效果及经济成本。方法选择银川市2家社区卫生服务中心480例2型糖尿病患者,根据就诊号分为4组,A组:二甲双胍0.25 g,tid,+阿卡波糖起始剂量为50 mg,渐增至100 mg;B组:二甲双胍0.25 g,格列美脲2 mg;C组口服格列齐特80 mg,渐增至160 mg;D组:二甲双胍0.25 g,瑞格列奈0.5 mg。以血糖值和糖化血红蛋白作为效果测量指标,12周后进行成本-效果分析。结果 A、B、C、D组成本分别为1 269.62、806.45、1 040.64、739.25元;对空腹血糖的总有效率分别为85.5%、86.1%、82.2%、88.6%,对餐后2 h血糖的总有效率分别为88.0%、90.0%、88.7%、90.3%;不论是空腹血糖或餐后2 h血糖,临床疗效差异无统计学意义,而方案D的成本最小。结论不论是控制空腹血糖还是控制餐后血糖,瑞格列奈+二甲双胍联用组为最佳方案。
Objective To evaluate four different drugs in the treatment of community - based type 2 diabetes and economic costs. Methods 480 cases of in - patients with type 2 diabetes were randomly divided into four groups to carry out two kinds of combination treatment,and cost -effectiveness was analyzed 12 weeks after treatment . Four different groups as follow：Group A, metformin ＋ acarbose ; Group B, metformin ＋ glimepiride; Group C, gliclazide ; Group D, metformin ＋ repaglinide. Results The costs in Group A, B, C and D were respectively 1557.66 yuan,806.45 yuan, 1040.64 yuan and 739.25 yuan. The total effective rates of blood sugar control on blood -fasting sugar were 85.5% ,86.1% ,82.2% and 88.6% ,respectively;and the total effective rates on control of blood sugar 2 hours after meal were 88.0% ,90.0%, 88.7% and 90.3%, respectively. Conclusion It is best to use Repaglinide and Metformin to control blood - fasting sugar level and blood sugar 2 hours after meal.
出处
《宁夏医学杂志》
CAS
2013年第5期404-406,共3页
Ningxia Medical Journal
