摘要
目的观察陷胸合剂合及贝藕糊剂治疗反流性食管炎(RE)的临床疗效。方法 200例患者随机分为2组。治疗组100例,口服陷胸合剂合及贝藕糊剂;对照组100例,口服奥美拉唑等药。2组疗程均为8周。观察治疗前后临床症状疗效、临床症状积分变化、胃镜疗效、胃镜下RE分组及积分评价、复发情况比较。结果临床症状总有效率治疗组为93%,对照组为84%,2组比较,有显著性差异(P<0.05)。治疗后2组患者各症状积分和总积分均有下降,与治疗前比较,有显著性差异(P<0.05),治疗后2组比较,在烧心、反酸、胸骨后疼痛改善方面有显著性差异(P<0.05),但在吞咽困难改善方面差异无统计学意义(P>0.05)。治疗8周后胃镜复查总有效率治疗组为93%,对照组为84%,2组比较,有显著性差异(P<0.05)。治疗后2组胃镜RE分级比较均有下降,2组治疗前后及治疗后比较均有非常显著性差异(P<0.01)。停药6个月后复发率治疗组为5.56%,对照组为30.43%,有显著性差异(P<0.05)。结论陷胸合剂合及贝藕糊剂治疗RE疗效明显优于对照药,复发率低,可以提高患者的生活质量。
OBJECTIVE To observe the clinical effects of Xianxiong Mixture and Beiou Cataplasm for treating reflux esoph- agitis （RE）. METHODS 200 patients were randomized into treatment group （100 eases treated by Xianxiong Mixture and Beiou Cataplasm） and control group （100 cases treated by omeprazole）. The treatment course for both groups are 8 weeks. The effects and integral changes of clinical symptoms, effects of gastroscope, RE grouping and integral evaluation under gas- troscope, and relapse were compared before and after the treatment. RESULTS The total effective rate of the treatment group is 93% and control group 84%. There was significant difference between the two groups （P〈0.05）. The integral and total in- tegral of each symptom in both groups all decreased. Compared with the condition before the treatment group, there was sig nificant difference （P〈0.05）. After the treatment, significant difference exists in the symptom improvement of burning heart, reflux, retrosternal pain but no significant difference exists in the symptom improvement of dysphagia. The total effective rate of treatment group is 93 % and control group 84% by gastroscope reexamination after 8 weeks. There was significant difference between the two groups （P〈0.05）. The gastroscope RE grading in both groups declined after the treatment. After adminis- tration of 6 months, the recurrence rate of treatment group is 5.56%and control group 30.43% and there was significant difference （P〈0.05）. CONCLUSION The therapeutic effects of Xianxiong Mixture and Beiou Cataplasm for treating RE is better than that of the control group. At the meanwhile, it has low recurrence rate and can enhance the life quality of the pa- tients.
出处
《南京中医药大学学报》
CAS
CSCD
北大核心
2013年第3期223-226,共4页
Journal of Nanjing University of Traditional Chinese Medicine
基金
江苏省老中医药专家学术经验继承专项(SC200962)
关键词
反流性食管炎
陷胸合剂
及贝藕糊剂
临床观察
reflux esophagitis （RE）
Xianxiong Mixture
Beiou Cataplasm
clinical observation.
