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胃癌中微小RNA相关研究进展

Progression of microRNA in gastric cancer
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摘要 近期大量研究发现微小RNA在胃癌的发展、诊断、治疗与预防等方面都起着关键性作用。已有报道证实miR-451可以作为一种有用的生物标志物用于胃癌的筛查，miR-203、miR-21可能成为胃癌诊断的标志物。微小RNA既可以发挥癌基因作用，也可以发挥抑癌基因作用，如miR-141通过对正成纤维细胞生长因子受体2基因表达的抑制来发挥抑癌基因的作用。 Recently, many studies find that microRNA plays a key role in the development, diagnosis, treatment and prevention of gastric cancer. It is confirmed that miR-451 can be used as a useful biomarker for the screening of gastric cancer. Studies also show that miR-203 and miR-21 may become diagnostic markers of gastric cancer. MicroRNA can play the role of oncogenes, and also can play the role of tumor suppressor gene, such as miR-141 plays the role of tumor suppressor gene through inhibition of the positive fibroblast growth factor receptor 2 gene expression.
作者 韩静 凌志强
机构地区 浙江省肿瘤医院浙江省肿瘤研究所遗传室
出处 《国际肿瘤学杂志》 CAS 2013年第5期359-362,共4页 Journal of International Oncology
关键词 胃肿瘤 微RNAS Gastric neoplasms MicroRNAs
分类号 R735.2 [医药卫生—肿瘤]
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国际肿瘤学杂志
2013年 第5期

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