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蛋白质组学在肿瘤中的应用

Applications of proteomics in the research of tumors
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摘要 蛋白质组学是从细胞水平及整体水平研究蛋白质构成及其变化规律的新兴学科。近年来,蛋白质组学研究已在多种肿瘤中展开,并在阐明肿瘤发生发展机制、发现新的特异性标志物、药物治疗靶标以及肿瘤生物学行为预测等方面取得了一定的进展。 Proteomics is an emerging discipline which studies the composition of proteins and their transformation rules at the cellular level and the overall level. Recently, proteomics has been used in a variety of studies of tumors. And it has made some progresses in explaining the mechanisms of tumors' genesis and development, discovering new specific markers for tumors and new targets for" drug treatment, and forecasting tumors' biological behaviors.
作者 侯巍巍 侯刚
出处 《国际肿瘤学杂志》 CAS 2013年第5期335-338,共4页 Journal of International Oncology
关键词 蛋白质组学 肿瘤 肿瘤标记 生物学 Proteomics Neoplasms Tumor markers, biological
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参考文献23

  • 1Chong PK, Lee H, Loh MC, et al. Upregulation of plasma C9 protein in gastric cancer patients. Proteomics, 2010, 10 (18) :3210-3221.
  • 2Mohri Y, Mohri T, Wei W, et al. Identification of macrophage migra- tion inhibitory factor and human neutrophil peptides 1-3 as potential biomarkers for gastric cancer. Br J Cancer, 2009, 101 (2) :295-302.
  • 3Franco AT, Friedman DB, Nagy TA, et al. Delineation of a carcino- genic Helieobaeter pylori proteome. Mol Cell Proteomics, 2009, 8 (8) : 1947-1958.
  • 4Osaki M, Inoue T, Yamaguchi S, et al. MAD1 ( mitotic arrest defi- ciency 1 ) is a candidate for a tumor suppressor gene in human stom- ach. Virvhows Arch, 2007, 451 (4):771-779.
  • 5Qi Yj, He QY, Ma YF, et al. Proteomic identification of malignanttransformation-related proteins in esophageal squamous cell carcino- ma. J Cell Biochem, 2008, 104(5) :1625-1635.
  • 6Kim YS, Hwang SY, Kang HY, et al. Functional proteomics study reveals that N-Acetylglucosaminyhransferase V reinforces the invasive/ metastatic potential of colon cancer through aberrant glycosylation on tissue inhibitor of metalloproteinase-1. Mol Cell Proteomics, 2008, 7 (I) :l-14.
  • 7Cai XW, Shedden K, Ao X, et al. Plasma proteomic analysis may i- dentify new markers for radiation-induced lung toxicity in patients with non-small-cell lung cancer. Int J Radiat Oncol Biol Phys, 2010, 77 (3) :867-876.
  • 8Yao H, Zhang Z, Xiao Z, et al. Identification of metastasis associated proteins in human lung squamous carcinoma using two-dimensional difference gel electrophoresis and laser capture microdissection. Lung Cancer, 2009, 65( 1 ) :41-48.
  • 9Planque C, Kulasingam V, Smith CR, et al. Identifcation of five can- didate lung cancer biomarkers by proteomic analysis of conditioned media of four lung cancer cell lines. Mol Cell Proteomics, 2009, 8 (12) :2746-2758.
  • 10Van Winden AW, Gast MC, Beijnen JH, et al. Validation of previ- ously identified serum biomarkers for breast cancer with SELDI-TOF MS: a case control study. BMC Med Genomics, 2009, 2:4.

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