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骨形态发生蛋白与肿瘤

Bone morphogenetic proteins and tumors
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摘要 骨形态发生蛋白（BMP）是一种多功能的细胞因子，不仅可以促进新骨形成，而且参与调控细胞生长、分化、迁移、凋亡以及胚胎和器官发生等过程。研究显示BMP还与肿瘤的发生和转移密切相关，在肿瘤治疗中具有重要的应用价值。 Bone morphogenetic proteins （BMPs） are multi-functional growth factors, they are found not only inducer of new bone formation, but also have critical roles in cell growth, differentiation, migration, apoptosis, embryogenesis and organogenesis. Studies show that BMPs are closely related to tumorigenesis and metastasis, which have important practical values in tumour therapy.
作者 米东 张月香 陈淑琴 祁珮
机构地区 天津市中心妇产科医院检验科
出处 《国际肿瘤学杂志》 CAS 2013年第5期323-325,共3页 Journal of International Oncology
关键词 骨形态发生蛋白质类 肿瘤 治疗 Bone morphogenetic proteins Neoplasms Therapy
分类号 R730.2 [医药卫生—肿瘤]
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参考文献15

  • 1Busch C, Drews U, Garbe C, et al. Neural crest cell migration of mouse BI6-F1 melanoma cells transplanted into the chick embryo is inhibited by the BMP-antagonist noggin. Int J Oncol, 2007, 31 (6) : 1367-1378.
  • 2Langenfeld EM, Kong Y, Langenfeld J. Bone morphogenetic protein 2 stimulation of tumor growth involves the activation of Smad-1/5. Oncogene, 2006, 25(5) :685-692.
  • 3AlarmoEL, Kuukasjarvi T, Karhu R, et al. A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7. Breast Cancer Res Treat, 2007, 103 (2) :239-246.
  • 4Ketolainen JM, Alarmo EL, Tuominen VJ, et al. Parallel inhibition of cell growth and induction of cell migration and invasion in breast cancer cells by bone morphogenetic protein 4. Breast Cancer Res Treat, 2010, 124(2) :377-386.
  • 5Shon SK, Kim A, Kim JY, et al. Bone morphogenetie protein-4 induced by NDRG2 expression inhibits MMP-9 activity in breast canc- er cells. Biochem Biophys Res Commun, 2009, 385 (2) : 198-203.
  • 6Zhao H, Ayrauh O, Zindy F, et al. Post-transcriptional down-regula- tion of Atohl/Mathl by bone morphogenic proteins suppresses medul- loblastoma development. Genes Dev, 2008, 22(6) :722-727.
  • 7Piccirillo SG, Reynolds BA, Zanetti N, et al. Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initia- ting cells. Nature, 2006, 444(7120) :761-765.
  • 8Yang S, Du J, Wang Z, et al. Dual mechanism of deltaEF1 expres- sion regulated by bone morphogenetic protein-6 in breast cancer. Int J Biochem Cell Biol, 2009, 41 (4) :853-861.
  • 9Takahashi M, Otsuka F, Miyoshi T, et al. Bone morphogenetic pro- tein 6 (BMP6) and BMP-/ inhibit estrogen-induced proliferation of breast cancer cells by suppressing p38 mitogen-activated protein kinase activation. J Endocrinol, 2008, 199 ( 3 ) :445-455.
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国际肿瘤学杂志
2013年 第5期

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