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HIF-1表达在肿瘤生长及演进中的作用 被引量：2

Role of HIF-1 expression in invasion and metastasis of malignant tumor
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摘要 恶性肿瘤细胞异常增殖的代谢模式,引起氧供应失衡,形成特异性肿瘤缺氧微环境。缺氧通过活化缺氧诱导因子-1(hypoxia induced factor-1,HⅠF-1)发挥功能,肿瘤细胞中过表达的HⅠF-1在多种恶性肿瘤生长、演进及放射治疗和化学治疗抵抗中起到关键作用。 Abnormally accelerated proliferation and metabolism are typical characteristics of malignant tumor cells, which lead to an imbalance between oxygen supply and oxygen consumption in a solid tumour and formation of tumorspecific microenvironment--hypoxia. Hypoxia exerts many effects through activation of a transcription factor-- hypoxia-inducible factor 1 （HIF-1）. Overexpression of HIF-1 contributes to cancer development, progressionj resistance to chemo as well as radiation therapy.
作者 王丽婷 张声
机构地区 福建医科大学附属第一医院病理科
出处 《国际病理科学与临床杂志》 CAS 2013年第2期150-154,共5页 Journal of International Pathology and Clinical Medicine
基金 福建医科大学第一临床学院学科带头人培养对象专项基金(JXK200724)~~
关键词 缺氧诱导因子-1 进展 治疗 肿瘤 hypoxia induced factor-l progression therapy tumor
分类号 R730.2 [医药卫生—肿瘤]
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参考文献20

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同被引文献24

  • 1吴强,杨述华,叶树楠.缺氧对骨肉瘤SaOS-2细胞系HIF-1α和VEGF表达的影响[J].中国癌症杂志,2004,14(6):501-504. 被引量：2
  • 2茅文斌,邵增务,裴洪,熊琪.骨肉瘤组织中HIF-1α、iNOS与GLUT-1的表达及其与血管生成的关系[J].中国癌症杂志,2007,17(1):46-49. 被引量：4
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  • 4Zhang XM, Yang S, Zhang Y. Stimulation by melittin of Na ^+ -Ca^2 + exchange current in ventricular myocytes of guinea pigs [ J ]. Acta Pharmacol Sin,2001,22( 1 ) :10-14.
  • 5Zhang XM, Yang S, He XJ, et al. Effect of melittin on potassium currents and action potential in ventricular myocytes of guinea pig [J ]. Acta Pharmacol Sin,2000,21 ( 9 ) : 841 - 844.
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  • 7Lazarev VN, Parfenova TM, Gularyan SK. Induced expression of melittin, an antimicrobial peptide, inhibits infection by Chlamydia trachomatis and Mycoplasma hominis in a HeLa cell line [ J ]. Int J Anti microb Agents,2002,19 (2) : 133-137.
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  • 9Wang J, Wu K, Bai F, et al. Celecoxib could reverse the hypoxia- induced angiopoietin-2 upregulation in gastric cancer[J]. Cancer Lett,2006,242( 1 ) :20-27.
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国际病理科学与临床杂志
2013年 第2期

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