摘要
目的探讨ABO血型不合对清髓异基因造血干细胞移植(allo-HSCT)造血重建的影响。方法选取2007年4月至2011年12月在温州医学院附属第一医院接受ABO血型不合清髓allo-HSCT21例受者和同期接受ABO血型相合allo-HSCT20例受者,观察两组红细胞系、粒细胞系、血小板重建情况。结果与ABO血型相合组比较,血型不合组红细胞系重建时间明显延长(中位时间分别为20d和10.5d,P<0.05),粒细胞和血小板植活时间差异均无统计学意义(均P>0.05)。血型主要不合、次要不合、主次要均不合3个亚组红细胞系重建时间差异无统计学意义(P>0.05)。Cox比例风险模型多因素分析结果显示,移植物中CD34+细胞数量是影响ABO血型不合组红细胞系重建时间的因素(P<0.05)。结论 ABO血型不合受者可以进行清髓allo-HSCT,CD34+细胞数量是影响ABO血型不合造血重建的主要因素。
Objective To investigate the effect of ABO-incompatible myeloablative allogeneic hematopoietic stem cell transplantation （allo-HSCT） on hematopoietic engraftment. Methods The clinical data of 21 patients who received ABO-incompatible allo-HSCT in the First Affiliate Hospital of Wenzhou Medical College from April 2007 to December 2011 were analyzed. Twenty patients matched who received ABO-compatible a11o-HSCT in the same period served as controls. Blood routine examination was dynamically observed and analyzed between the 2 groups. Results The recovery of erythrocytic series reconstitution was prolonged to 20 d in ABO-incompatible patients as compared to 10.5 d in ABO-compatible patients （ P 〈 0. 05 ）. No difference in platelet and the neutrophil reconstitution was noted between the ABO-compatible and ABO-incompatible patients （P 〉 0. 05 ）. Time of red blood cells engraftment was not different among major, minor, and bidirectional ABO- incompatible groups （ P 〉 0.05 ）. Cox proportional hazard model analysis demonstrated that number of CD34^＋ ceils were correlated with erythrocytic series in ABO-incompatible patients （P 〈 0.05 ）. Conclusions Myeloablative allo- HSCT is safe in ABO- incompatible patients if there is any indication. The number of CD34 ＋ cells are correlated with erythrocytie series.
出处
《中华移植杂志（电子版）》
CAS
2012年第4期11-14,共4页
Chinese Journal of Transplantation(Electronic Edition)
基金
温州市科技计划项目(2012S0146)
关键词
ABO血型
异基因造血干细胞移植
造血重建
ABO blood group
Allogeneie hematopoietie stem cell transplantation
Hematopoietie engraftment
