摘要
目的 :通过对感染性心内膜炎 (IE)使用抗菌药物的分析 ,探讨 IE抗菌药物的合理选用。方法 :对广东省人民医院近 5年 187例 IE患者的抗菌药应用情况进行回顾性分析。结果 ::青霉素类、头孢菌素类、氨基糖苷类和喹诺酮类的使用频率位于前 4位。在各种抗菌药中 ,青霉素、丁胺卡那霉素的 DDDs居前 2位 ,远高于其他药物。除苯唑青霉素外 ,其他抗生素的药物利用指数 (DUI)均≤ 1。青霉素类与氨基糖苷类的联合是最常用的治疗方案。结论 :IE的治疗中抗菌药的使用存在某些不合理 ,应根据细菌培养结果及应用指征合理选择抗菌药。
AIM: To evaluate the result of antibiotics treatment in patients with infective endocarditis (IE) so as to improve the treatment. METHODS: One hundred and eighty seven IE cases hospitalized at Guangdong provincial hospital were retrospectively analysed. RESULTS: Penicillin, cephalosporins, aminoglycosides and 4 quinolones were the most commonly used among different antibiotics. The most common 2 drugs used in patients with IE were penicillin G and amikacin. Drugs utilization index (DUI) of these antibiotics were ≤0 1, except oxacillin. Penicillin combined with aminoglycosides was the most frequently used antibiotic in different therapeutic protocols. CONCLUSION: Our results show that administration of some antibiotics are not rational in patients with IE. Antibiotics should be selected according to results of bacteria culture and indications of drugs.
出处
《中国临床药学杂志》
CAS
2000年第4期234-236,共3页
Chinese Journal of Clinical Pharmacy
关键词
感染性心内膜炎
抗生素
药物利用
infective endocarditis
antibiotics
drug utilization
