摘要
目的 :研究前列腺素 E1 (PGE1 )对老年人颈动脉斑块的影响。方法 :选择颈动脉彩色多普勒检查存在斑块的脑梗死或短暂性脑缺血发作 (TIA)的入院患者 41例 ,予 PGE1 10 ︼g溶于 10 m l生理盐水 iv,qd,连续 2 wk,测定治疗前后患者的凝血功能、血小板聚集度、颈动脉彩色多普勒检查及常规生化检查。结果 :治疗前后患者颈动脉内径有所扩大 (P<0 .0 5 ) ,血液流变学得到改善 ,颈动脉内斑块大小均有统计学意义的减小 (P<0 .0 1) ,并且血黏度 (P<0 .0 1)及血小板聚集度 (P<0 .0 1)也有明显改善 ,但血小板的计数无改变 (P>0 .0 5 )。结论 :PGE1 在减小颈动脉斑块及改善血液流变学上有其独特的作用。
AIM: To study the changes of artherosclerosis plaque on carotid artery in the elder after treating with prostaglandin E 1 (PGE 1). METHODS: Forty one elders hospitalized for stroke or TIA were confirmed to have artherosclerosis plaques on the carotid arteries by Dopplar ultrasonography examination. All these patients were given PGE 1 10 μg iv qd×2 wk. Before and after treatment, Dopplar ultrasonography and laboratory tests were performed, including platelet aggregation, platelet count, blood viscosity and blood pressure. RESULTS: The initial diameter of carotid artery was significantly enlarged ( P <0 05). The size of artherosclerosis plaque decreased ( P <0 01). The other laboratory examinations such as blood viscosity ( P <0 01) and platelet aggregation ( P <0 01) were also significantly improved. The drug showed no significant effect on platelet count and blood pressure. CONCLUSION: PGE 1 has a special effect in the treatment of artherosclerosis plaques.
出处
《中国临床药学杂志》
CAS
2000年第4期217-219,共3页
Chinese Journal of Clinical Pharmacy
