摘要
树突棘是神经元树突上的功能性突起结构，形成兴奋性突触。树突棘内含有细胞表面受体、肌动蛋白细胞骨架、脚手架蛋白等多种成分，它们对树突棘的生长发育成熟以及结构的稳定起调节作用。树突棘内的多种成分不仅在维持其形态和结构上有表达作用，而且在功能上参与表达，树突棘形态与功能密切相关，其形态受很多因素的影响，处于不断的调整变化中。因而树突棘可塑性是中枢神经系统突触功能的一个重要方面，与大脑的学习记忆功能和中枢神经系统疾病密切相关。
Dendritic spines are functional protrusions on neuron dendrites and formation of excitatory synaptic sites. Dendritic spines contain a variety of cell surface receptors, actin cytoskeleton, scaffolding proteins and other components,which regulate the growth of dendritic spines maturation and structure. Multiple compo-nents within dendritic spines not only have effects on expression of its shape and structure, but also on the func-tion. Morphology of dendritic spines is closely related with its function. Its shape is affected by many factors in the changing process. So dendritic spine plasticity is an important aspect of synaptic function in the central nerv-ous system, and is closely related with learning and memorv function and central nervous system diseases.
出处
《国际儿科学杂志》
2013年第3期287-289,共3页
International Journal of Pediatrics
关键词
树突棘
可塑性
学习记忆
衰老
Dendritic spines
Plasticity
Learning and memory
Aging
