摘要
目的 :探讨胃肝样腺癌的病理组织学特点及生物学行为。方法 :分析经手术及病理证实的胃肝样腺癌 11例 ,并应用免疫组化染色及电镜观察。结果 :胃肝样腺癌 ,光镜下最具特征的组织学表现为玻璃样小体、广泛性侵犯静脉 ;免疫组化AFP、AAT、ACT阳性 ,HCG阴性 ;电镜下 ,可见癌细胞围成腔样 ,类似于毛细胆管结构 ,腔面有微绒毛 ,细胞膜相连处有连接复合体。随访 1～ 5年 ,死亡 6例 ,其中 5例死于胃肝样腺癌广泛转移 ,1例死于腹腔种植性转移。其余随访中均存活。结论 :胃肝样腺癌是原发于胃粘膜并具有腺癌和肝细胞癌特征的一种胃癌 ,分化差 ,易肝转移 。
Purpose To investigate the morphogical features,biological behavior and diagnosis of gastric hepatoid adenocarcinoma(GHA). Methods Eleven hepatoid carcinomas of the stomach were evaluated on the basis of characteristic histologic features. Immunohistochemical method and electron microscopy were used to study the immunophenotype and ultrastructural features. Results Histologically,hyaline globules and venous invasion were common features in GHA. An immunohistochemical study showed that the tumor cells were positive for AFP, AAT, ACT, but negative for HCG. Ultrastructurally,tumor cells were arranged toward the lumens.There were microvilli on the luminal surfaces.There were junctional complexes between the lateral plasma membranes of adjacent tumor cells. Conclusions GHA is a special type of primary gastric carcinoma characterized by both the histologic strutures of hepatoid differentiation and adenocarcinoma. Thus, GHA should be paid attention because it has a poor prognosis due to frequent liver metastases. The correct diagnosis before operation and right treatment may aid in improving the prognosis of GHA.
出处
《临床与实验病理学杂志》
CAS
CSCD
2000年第4期301-303,共3页
Chinese Journal of Clinical and Experimental Pathology
