摘要
目的 了解血管加压素在心脏重构中的作用。方法 对腹主动脉 -下腔静脉分流术后的大白鼠应用血管加压素V1受体拮抗剂 (OPC - 2 12 6 8)治疗 ,4周后观察。结果 分流术后 4周出现心排量降低 ,心率增快 ,左室收缩压降低 (P均 <0 .0 5 )及左室舒张末期压和右房压增高 (P均 <0 .0 1) ;出现心脏增大 ,心脏重量增加 (P<0 .0 1) ,左心室壁厚度增加 (P <0 .0 1)及心肌细胞肥大。OPC - 2 12 6 8治疗 4周后 ,左心室壁厚度明显缩小 (P <0 0 1) ,未见两心室的明显扩大及心肌细胞的肥大。结论 A -C分流术后发生了心肌肥大 ,OPC - 2 12 6 8能够阻止心肌细胞肥大。
Objective To investigate the action of vasoprssin on heart remoulding by the treatment of OPC-21268 in aortal-caval shunt rats.Method The vasopressin V1 receptor antagonist(OPC-21268)was applied to the A-C shunt rats and observe the results four weeks later.Results\ Rats with A-C shunt 4 weeks later would manifest heart failure which was characteristic of an increase in total heart weight(P<0.01),thickness of left ventricular wall (P<0.01),heart rate (P<0.05),LEVDP(P<0.01),RAP(P<0.01)and a decrease in cardiac output(P<0.05),LVSP(P<0.05).After 4 weeks' treatment,the thickness of left ventricular wall obviously decreased with no enlargement of the left and right ventricle and myocyte hypertrophy.Conclusion\ Myocyte hypertrophy in A-C shunt rats can be inhibited by OPC-21268.
出处
《中国实用内科杂志》
CSCD
北大核心
2000年第8期466-468,共3页
Chinese Journal of Practical Internal Medicine
