摘要
目的:观察卡培他滨同步三维适形放疗(3D-CRT)治疗老年食管癌根治术后局部复发的疗效及安全性。方法:采用回顾性分析方法,按照是否同步化疗将62例患者分为治疗组(卡培他滨同步3D-CRT)与对照组(3D-CRT),各31例。治疗组给予卡培他滨1000mg/m2,早晚2次,餐后30min口服,d1～14,21d为1个周期。评价完成2个周期的疗效、不良反应和远期疗效。结果:治疗组与对照组的有效率分别为83.87%、54.84%(P<0.05),1～2度胃肠道反应发生率分别为48.39%、25.81%(P<0.05),1～2度骨髓抑制发生率分别为35.48%、22.58%(P<0.05),1年局部控制率分别为70.97%、45.16%(P<0.05)。结论:卡培他滨同步3D-CRT治疗老年食管癌根治术后局部复发疗效确切,不良反应增加但均可耐受。
OBJECTIVE： To observe the therapeutic effect and safety of capecitabine combined with 3D-CRT in the treatment of local recurrence in elderly patients after esophageal cancer radical surgery. METHODS： By retrospective study, 62 patients were randomly assigned into treatment group （capecitabine combined with 3D-CRT） and control group （3D-CRT） with 31 cases in each group. Patients in treatment group were given capecitabine 1 000 mg/m2, bid, po, half an hour after dinner, dl-14, 21 days for a course. Therapeutic efficacy, adverse drug reaction and long-term efficacy were analyzed and compared after two courses. RE- SULTS： The effective rates of treatment group and control group were 83.87% and 54.84% （P〈0.05）; the incidence of gastroin- testinal reaction were 48.39% and 25.81% （P〈Z0.05）; those of grade I -lI bone marrow inhibition were 35.48% and 22.58% （P〈 0.05） ： 1 year local control rate were 70.97% and 45.16% （P〈0.05）. CONCLUSIONS： Capecitabine combined with 3D-CRT has an exact curative effect on local recurrence in the elderly patients after esophageal cancer radical surgery, and the side effects are in- creasing but can be tolerated.
出处
《中国药房》
CAS
CSCD
2013年第22期2075-2077,共3页
China Pharmacy
关键词
卡培他滨
同步三维适形放疗
老年
食管癌
根治术后
局部复发
Capecitabine
Combined with 3D-CRT
Elderly
Esophageal cancer
After radical surgery
Local recurrence
