摘要
目的 通过对 18三体胚鼠和正常胚鼠的比较形态测量学研究 ,量化地认识该腭裂模型大体及颅颌面先天性发育不足。方法 采用 6 0只Han NMRI母鼠及 11只具有Rb(2 18) 6Rma/Rb(1 18)Rma染色体结构的雄鼠 ,从 5 6 9只子代活胚中选择 5 2对胎鼠作为研究对象 ,其中每对包括一只正常胎鼠和一只与正常胎鼠体重相近的三体伴发腭裂的胎鼠。借助大体形态测量学手段对 5 2对样本进行形态学测量研究。结果 腭裂小鼠脊柱明显屈曲 ,且伴有上、下颌骨后缩畸形 ,下颌骨较上颌骨更明显。结论 18三体伴腭裂实验动物模型伴有明显的脊柱发育畸形及上、下颌骨的严重发育不足。
Objective To quantitatively compare the whole body, the lateral maxillofacial profile in Ts18 foetuses with cleft palate (Ts+CP) and euploid foetuses in order to answer the question whether this animal model is associated with maldevelopment or hypoplasia of the craniomaxillofacial region Methods Sixty female Han- mice and 11 male mice with the Rb(2 18)6Rma and Rb(1 18) 10Rma chromosomes were used to generate 569 living foetuses Of these, 52 pairs Ts+CP and euploid foetuses were selected according to about equal body weight, and used in gross morphometric study Results Ts+18 foetuses had greater body flexion, a significant maxillary and mandibular retrusion , also mandible in Ts+CP foetuses were smaller than in euploids without cleft Conclusions This animal model of congenital cleft palate developed hypoplasia of the maxilla and mandible
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
2000年第5期371-373,共3页
Chinese Journal of Stomatology
