摘要
目的提高对儿童原发性中枢神经系统间变性大细胞性淋巴瘤(ALCL)侵及脑膜伴脑脊液播散的认识,减少对ALCL的误诊。方法对1例ALCL临床资料进行分析,光镜观察脑脊液细胞学特征,原发部位组织学形态结构和免疫表型,并复习文献。结果中枢神经系统ALCL侵及脑膜,肿瘤细胞在脑脊液中出现,形态多样,核膜不清,核分裂可见。形态特征与原发部位肿瘤细胞相似,免疫组化:ALK、TIA和GRB(+),GFAP和Neu-N(-),Ki-67增殖指数为60%。p53 3%(+)。结论中枢神经系统是ALCL的少发部位,脑脊液中肿瘤细胞的检出有助于提高ALCL的诊断。
Objective To make doctors better understanding of primary central nervous system （PCNS） anaplastic large cell lymphoma （ALCL） and to reduce misdiagnosis of ALCL at an earlier stage. Methods The clinical data of a ALCL case were analyzed, and cerebrospinal fluid cells, histopathological structure and immunophenotype at the primary locus were observed through microscopy, with review of related literature. Results PCNS ALCL infiltrated meninges, and the tumor cells in cerebrospinal fluid exhibited similarity to the tumor cells in the primary locus. The diagnosis was verified through immunohistochemistry in the primary lesion. Conclusions ALCL of CNS is rare, and the finding of tumor cells in cerebrospinal fluid helps in ALCL diagnosis.
出处
《诊断病理学杂志》
CSCD
北大核心
2013年第5期303-306,共4页
Chinese Journal of Diagnostic Pathology
关键词
大细胞性淋巴瘤
原发性中枢神经系统
脑脊液
儿童
Large cell lymphoma
Primary central nervous system
Cerebrospinal fluid cell
Child
