摘要
目的:探讨不同剂量舒洛地特治疗临床期糖尿病肾病患者的疗效。方法:入选临床期糖尿病肾病患者,分为常规治疗组、常规治疗+小剂量舒洛地特组、常规治疗+大剂量舒洛地特组,以24 h尿蛋白(TP/24 h)小于0.15 g或下降基础值50%作为治疗有效,评价各组患者治疗有效性。结果:随访16周,常规治疗组、小剂量舒洛地特组和大剂量舒洛地特组有效性分别为10%、14.3%和63.6%,停用舒洛地特进入洗脱期8周后,大剂量舒洛地特组治疗有效性下降至27.2%,但与常规治疗组相比,仍具有统计学意义(P<0.05)。结论:大剂量舒洛地特可以有效降低临床糖尿病肾病患者尿蛋白,值得进一步研究。
Objective： To investigate the effect of sulodexide on urine protein excretion in type 2 diabetes with proteinuria.Methods： Type 2 diabetic nephropathy patients were divided into the conventional therapy group,the conventional treatment plus low-dose sulodexide group,and conventional treatment plus highdose sulodexide group.The standard of effectiveness was 24-hour urinary protein（TP/24 h） lower than 0.15 g or decreasing by 50% from baseline.Results： After followed up for 16 weeks,the effective rate in the above three groups was 10%,14.3% and 63.6% respectively.At the 8th week of wash-out phase after discontinuation of sulodexide,the effective rate of conventional treatment plus high-dose sulodexide group decreased to 27.2%,but it was still statistically significant（P 0.05） higher than that of conventional therapy group.Conclusion： High-dose sulodexide was effective in decreasing urine protein excretion in patients with type 2 diabetic nephropathy.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2013年第3期450-452,456,共4页
Medical Journal of Wuhan University
关键词
糖尿病肾病
舒洛地特
Diabetic Nephropathy
Sulodexide
