摘要
目的:回顾性研究177例Ⅱ期乳腺癌患者术后辅助治疗是否规范对预后的影响。方法:纳入2000年1月至2005年12月在我院行术后辅助治疗且符合条件的177例乳腺癌患者的临床以及病理资料,探讨患者术后辅助治疗、年龄、绝经状况、淋巴结清扫、TNM分期、雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体2(HER-2)、初发到治疗的时间、术式、病理类型、手术地点等与预后的相关性。结果:本组病例中位随访时间为62个月,随访率为82.49%,其中仅53例患者(29.94%)接受了规范辅助治疗。术后辅助治疗规范组与非规范组的5年总生存率分别为98.11%和93.58%,10年总生存率分别为80.66%和61.57%,两组之间存在统计学差异(P<0.05)。此外,与Ⅱ期乳腺癌患者预后有关的独立因素还包括绝经状况、HER-2状态(P<0.05),而年龄、淋巴结清扫个数、TNM分期、初发到治疗时间、病理类型不能成为影响患者预后的独立因素(P>0.05)。结论:术后规范辅助治疗、绝经状况及HER-2与Ⅱ期乳腺癌患者的预后密切相关。
Objective： To investigate the postoperative adjuvant therapy effect and prognosis factor in 177 stage Ⅱ breast cancer,and to explore the relationship between the clinicopathological factors and patients’ prognosis.Methods： The clinical/pathological materials of 177 stage Ⅱ breast cancer cases were collected between Jan.2000 and Dec.2005 who received postoperative adjuvant treatment,including radiotherapy,chemotherapy and endocrine therapy.Age,menstruation,stages,pathological types,lymph node dissection,the expression of estrogen receptor（ER）,progestrone receptor（PR）,and human epidermal growth factor receptor-2（HER-2）,surgical method types,and postoperative adjuvant therapy were evaluated in relation to the prognosis of breast cancer.Results： In 177 stage Ⅱ breast cancer cases,only 29. 94% cases were compliance with NCCN guidelines,and mean follow-up time was 62 months.Analysis revealed that overall survival of this group were significantly associated with menopausal status,HER-2 status,and adjuvant treatment（P 0.05）,while patients’age,the number of dissected lymph nodes, TNM staging,time interval between onset and treatment,pathology type had no significant independent prognosis value（P 0.05）.Conclusion： Our data demonstrate that menopausal status,HER-2 status, incipient symptoms,and adjuvant treatment are significant independent indicators of prognosis in stage Ⅱ breast cancer respectively.Compliance with NCCN guidelines for postoperative adjuvant treatment of stage Ⅱ breast cancer was low,and adjuvant treatment should follow NCCN guidelines.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2013年第3期377-380,384,共5页
Medical Journal of Wuhan University
关键词
乳腺癌
术后辅助治疗
预后
Breast Cancer
Postoperative Adjuvant Therapy
Prognosis
