摘要
目的探讨子宫内膜异位症(EMS)患者腹腔液及血清中视黄醇结合蛋白4(RBP4)的变化以及与肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)的相关性,研究其在EMS发病中的地位。方法通过采用酶联免疫吸附双抗体夹心法(ELISA)检测56例EMS患者(I^II期32例,Ⅲ~Ⅳ期24例)和30例对照组(同期因良性卵巢囊肿或者浆膜下子宫肌瘤或者腹腔镜检查正常的病人住院手术的患者)腹腔液及血清中RBP4,TNF-α和IL-6的含量进行分析。结果 EMS组腹腔液及血清RBP4,TNF-α和IL-6的水平均高于于对照组,差异有统计学意义(P<0.05);EMS组Ⅲ、Ⅳ期腹腔液和血清RBP4,TNF-α和IL-6的水平均高于Ⅰ、Ⅱ期腹腔液和血清水平,差异均有统计学意义(P<0.05);同时EMS组患者RBP4与TNF-α、IL-6的含量之间存在正相关,差异有统计学意义(P<0.05)。结论 EMS患者血清和腹腔中高水平的RBP4可能在EMS发病起到作用;EMS患者腹腔液与血清中RBP4与TNF-α、IL-6的相关性说明RBP4与EMS炎症反应关系密切。
Objective To investigate the concentrations of prostaglandin retinol binding protein 4 （RBP4） and in serum and peri- toneal fluid of women with endometriosis. Methods The study group included 56 samples of peritoneal fluid and serum respective- ly from patients with endometriosis, and control group included 30 samples of peritoneal fluid and serum respectively from patients without endometriosis.The peritoneal fluids and serum were collected at the time of laparoscopic operation. Concentrations of RBP4 and TNF-α, IL-6 were determined by enzyme linked immunosorbent assay （ELISA）. Results The peritoneal fluid and serum con- centrations of RBP4 and TNF-α, IL-6 in EMS group were significantly higher than those of control group （P〈0.05）; and the RBP4 and TNF-α,IL-6 levels of stage III, IV in endometriosis group were significantly higher than those of stage I , II in endometriosis group in serum and peritoneal fluid （P〈0.05）. There was positive correlation between the concentrations of RBP4 and TNF-α, IL-6 in endometriosis group （P〈0.05）. Conclusion The concentrations of RBP4 in peritoneal fluid were increased in endometriosis. The concentrations of RBP4 and TNF-α, IL-6 were associated with the extent of endometrosis lesions.
出处
《中外医疗》
2013年第13期9-10,12,共3页
China & Foreign Medical Treatment
