摘要
目的:探讨支气管肺泡灌洗液(BALF)半乳甘露聚糖(GM)的检测对侵袭性肺曲霉病(IPA)的早期诊断价值。方法:选择85例临床资料完整的患者,分为IPA组与对照组。采用酶联免疫夹心法半定量测定BALF GM和血清GM抗原,用统计学方法了解BALF GM检测的诊断效率。结果:以GM值为0.5作为阳性界值时,BALF GM和血清GM检测的敏感度、特异度、阳性预测值和阴性预测值分别为85.7%、81.2%、60.0%、94.5%;52.4%、89.1%、52.2%、95.0%。以GM值为1.0作为阳性界值时,BALF GM和血清GM的特异度、阳性预测值均可达100.0%,但BALF GM检测的敏感度和阴性预测值(66.7%和90.1%)明显高于血清GM检测(28.6%和81.0%)。结论:BALF GM试验以1.0作为阳性界值,对IPA的早期诊断有重要的应用价值。
Objective To evaluate the early diagnostic value of galactomannan detection in bronchoalveolar lavage fluid（BALF） for the invasive pulmonary aspergillosis（IPA）.Methods 85 cases were divided into IPA group and control group.GM in BALF and serum were detected by semi-quantitative of ELISA.Diagnostic efficiency of BALF GM detection were evaluated by statistics.Results GM value of 0.5 as the positive cutoff value,sensitivity,specificity,positive predictive value,and negative predictive values of GM in BALF and serum were respectively 85.7%,81.2%,60.0%,94.5% and 52.4%,89.1%,52.2%,95.0%.GM value of 1.0 as the positive cutoff value,specificity and positive predictive values of GM in BALF and serum could both be up to 100%,however sensitivity and negative predictive values of GM in BALF（66.7% and 90.1%） was significantly higher than that in serum（28.6% and 81.0%）.Conclusions GM value of 1.0 as the positive cutoff value in BALF GM test has important value on early diagnosis of IPA.
出处
《实用医学杂志》
CAS
北大核心
2013年第10期1677-1679,共3页
The Journal of Practical Medicine
