摘要
目的:探讨PW-TDI在评价血压正常及合并高血压2型糖尿病患者左、右心室收缩功能中的应用价值。方法:收集血压正常糖尿病患者(DM)24例,合并高血压糖尿病患者(DMHT)22例及正常对照组(NC)30例,应用常规二维超声和PW-TDI技术分别对以上3组患者左、右心室收缩功能进行评价,并对结果进行统计学分析。结果:常规测值在DM和DMHT组间及与NC组间比较无明显统计学差异。左室Ea、Aa、Ea/Aa、Sa、IVV、IVA在DM和DMHT组与NC组间比较差异均有统计学意义,其中Ea、Ea/Aa、Sa、IVV、IVA在DM和DMHT组间比较亦差异有统计学意义,另外E/Ea及Tei指数在DM和DMHT组间及与NC组间比较差异均有统计学意义。右心室Ea、Aa、Ea/Aa、E/Ea、IVA及Tei指数在DM和DMHT组与NC组间比较差异有统计学意义,其中E/Ea及Tei指数在DM和DMHT间比较差异有统计学意义,而IVA在两组间比较差异无统计学意义,Sa及IVV在各组间比较均差异无统计学意义。RVIVA与Ea/Aa呈正相关(r=0.31,P<0.01),与RVE/Ea呈负相关(r=-0.44,P<0.05),与RVTei指数呈负相关(r=-0.56,P<0.05)。结论:PW-TDI技术可以早期无创评价糖尿病患者左、右心室收缩和舒张功能的改变,并能早期反映出高血压对糖尿病患者左、右心室功能减低的程度。
Purpose： This study was to assess the preclinical effects of type 2 DM with or without hypertension （HT） on left and right ventricular （LV, RV） systolic function by using pulse Tissue Doppler Imaging （TDI）-derived indices. Methods： The study included three experimental groups, there were 24 simple type 2 DM patients, 22 type 2 DM patients with hypertension （DMHT） and 30 health adults as control group. Conventional 2D parameters and TDI-derived systolic velocities of bicuspid and tricuspid annulus were measured to evaluate left and right ventricular systolic function, the parameters of TDI included isovolumic myocardial acceleration （IVA）, peak myocardial velocity during isovolumic contraction （IVV）, peak systolic velocity during ejection period （Sa）, early diastolic velocity （Ea）, late diastolic velocity （Aa） , E/Ea, Ea/Aa, LV and RV Tei index. The results were analyzed by statistical methods. Results： Conventional parameters of left and right heart were similar in the three groups. Ea, Aa, Ea/Aa, Sa, IVV, IVA of LV were significantly lower in both DM and DMHT patients compared to control groups, that indicating subclinical impairment in LV systolic and diastolic function in the patient groups （P〈0.05）. Whereas E/Ea and Tei index were significantly higher, Ea, Ea/Aa and IVA were significantly lower in both DM and DMHT patients compared to control groups, that indicating subclinical impairment in RV systolic and diastolic function in the patient groups （P〈0.05）. Whereas Aa, E/Ea and Tei index were significantly higher. RV IVA was similarin DM and DMHT subgroup which supporting RV systolic impairment in DM was independent from HT. In correlation analysis, RV IVA was significantly correlated with the E/Ea ratio （r=-0.44, P〈0.05）, Ea/ Aa ratio （r=0.31, P〈0.01） and Tei index（r=-0.56, p〈0.05）. Conclusion： TDI can be used to evaluate the systolic and diastolic function of left and right ventricular in patients with type 2 diabetes early and noninvasively. Hypertension aggravates the function of left and right ventricular in patients with type 2 diabetes.
出处
《中国医学计算机成像杂志》
CSCD
北大核心
2013年第2期168-171,共4页
Chinese Computed Medical Imaging
关键词
糖尿病
2型
心室
组织多普勒
超声心动图
Diabetes, type 2
Ventricular, Tissue Doppler
Echocardiography
