摘要
目的:建立复方亚硒酸钠滴眼液中硫酸锌的含量测定方法。方法:以[4-(2-吡啶偶氮)]间苯二酚(PAR)与锌离子进行显色反应,生成络合物的最大吸收波长为493nm,在此波长下采用分光光度法进行定量测定。结果:硫酸锌检测质量浓度线性范围为0.406～4.06μg/m(lr=0.9999),平均方法回收率为100.07%,RSD=0.53%(n=9)。结论:建立的方法操作简便、快速,结果准确,适用于该产品的质量控制。
OBJECTIVE：To establish a method for the content determination of zinc sulfate in Compound sodium selenite eye drops.METHODS：[4-（2-Pyridinylazo）]-resorcinol（PAR）reacted with zinc ion to produce clathrate,and its maximum absorption wavelength was at 493 nm.Spectmphotometry was used for quantitative determination.RESULTS：The linear range of zinc sulfate were 0.406-4.06 μg/ml（r=0.999 9）with an average recovery of 100.07%（RSD=0.53%,n=9）.CONCLUSIONS：The method is simple,quick and accurate.It＇s suitable for quality control of the product.
出处
《中国药房》
CAS
CSCD
2013年第21期2005-2006,共2页
China Pharmacy
