摘要
目的探讨防御性应用佩尔地平对腹腔镜子宫肌瘤剔除术中垂体后叶素诱发心血管反应的有效性。方法选择拟在全麻下择期行腹腔镜子宫肌瘤剔除术患者40例,ASAⅠ或Ⅱ级,随机均分为:佩尔地平组(P组)和对照组(C组)。所有患者均在子宫肌瘤剔除操作前,经穿刺针于腹腔镜监视下刺入肌瘤周围肌层,注入垂体后叶素6U。于注射完毕后2min时,P组静注佩尔地平0.005mg/kg,C组静注生理盐水2ml。记录注射垂体后叶素前1min(T0)、用药后15s(T1)、30s(T2)、60s(T3)、90s(T4)、2min(T5)、5min(T6)、15min(T7)及30min(T8)患者的MAP、HR,记录手术时间及出血量。结果与T0时比较,T1～T3、T5时P组,T1～T4时C组MAP明显降低(P<0.05);T5～T8时C组MAP明显升高(P<0.05);T1～T4时两组HR明显增快(P<0.05)。与C组比较,T5～T8时P组MAP明显降低、HR明显增快(P<0.05)。两组患者手术时间和出血量差异均无统计学意义。结论腹腔镜子宫肌瘤剔除术患者局部注射垂体后叶素后2min静脉注射佩尔地平0.005mg/kg可有效防御垂体后叶素诱发的心血管反应。
Objective To investigate the efficacy of perdipine in preventing pituitrin-induced cardiovascular responses in patients undergoing laparoscopic myomectomy. Methods Forty patients （ASA [ orⅡ ）, aged 22-52 yr, weighted 50-65 kg, scheduled for laparoscopic myomectomy under general anesthesia were randomly assigned into two groups： control group （group C） and perdipine group （group P）. The mixture of pituitrin 6 U and normal saline 9 ml was injected into the site of hysteromyoma. And 2 rain later, perdipine （0. 005 mg/kg） was injected intravenously, while normal saline 2 ml was given in group C. The mean blood pressure and heart rate were recorded at 1 rain （T0） before injection of pituitrin, 15 s （T1）, 30 s （T2）, 60 s （T3）, 90 s （T4）, 2 rain （T5）, 5 rain （W6）, 10 rain （T7） and 30 rain （T8） after injection. The operation time and the amount of bleeding were also measured at last. Results The MAP in group C was reduced at T1-T4 （P〈 0.05）, but increased at Ts-T8 （P〈0.05） as compared with that at To. The MAP in group P was decreased at T1- T3 and T5 as compared with To （P〈0.05）. The HR is both groups was increased significantly from T1- T4 compared with To （P〈0.05）. In group P, the MAP at T5-T8 was significantly lower than that in group C （P〈0.05）, while HR at Ts-T8 was higher than that in group C （P〈0.05）. The operation time and the amount of bleeding in the two groups had no statistical differences. Conclusion Perdipine can effectively prevent pituitrin-induced cardiovascular response in laparoscopic myomectomy.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2013年第5期432-434,共3页
Journal of Clinical Anesthesiology
