摘要
目的了解1997～2008年出生儿童接种重组乙型肝炎(乙肝)疫苗(酿酒酵母)(Hepatitis B Vaccine Made by Recombinant Deoxyribonucleic Acid Techniquesin Saccharomyces Cerevisiae Yeast,HepB-SCY)后的抗体水平,评价HepB-SCY的免疫持久性及保护效果。方法在西宁市城西区、大通县和海南藏族自治州同德县,选择1997～2008年出生、有明确HepB-SCY免疫史的特定人群,每个年龄段100人左右,采集静脉血5ml,分离血清,检测乙肝病毒(Hepatitis B Virus,HBV)表面抗原、抗乙肝病毒表面抗原抗体、抗乙肝病毒核心抗原抗体三项血清学指标。结果接种HepB-SCY后1～12年抗体阳性率保持在较高水平,抗体几何平均浓度则呈现随免疫年限延长而逐渐下降趋势。免疫人群HBV感染率为4.82%,较实施免疫前明显下降。结论 HepB-SCY免疫后效果较持久,可有效预防接种人群HBV感染。
Objective To understand the long-term immune effects of hepatitis B vaccine made by recombinant deoxyribonucleic acid techniques in saccharomyces cerevisiae yeast （HepB-SCY）. Method To select the children from Chengxi, Datong and Tongde county of Qinghai province, who had been vaccinated HepB-SCY who were born from 1997 to 2008. 100 children were selected each year to check their hepatitis B vaccination history and test for Hepatitis B Virus （HBV）markers. Results The positive rate of anti-hepatitis B surface antibody maintained at higher level after vaccination for 12 years, however the geometric mean concentration of anti-hepatitis B surface antibody was decreased with years. The average HBV positive rate of the children was 4.82%. It revealed significant reduction compared with the teenagers before immunization. Conclusion The long-term immune effects of HepB-SCY was satisfied and it has good effects for preventing the infection of HBV.
出处
《中国疫苗和免疫》
CAS
2013年第2期150-153,共4页
Chinese Journal of Vaccines and Immunization
基金
国家科学技术重大专项艾滋病和病毒性肝炎等重大传染病防治专项我国乙型病毒性肝炎免疫预防策略研究课题(编号:2008ZX10002-001)
关键词
乙型病毒性肝炎
重组乙型肝炎疫苗(酿酒酵母)
免疫持久性
Viral hepatitis B
Hepatitis B vaccine made by recombinant deoxyribonucleic acid techniques in saccharomyces cerevisiae yeast
Immune persistence
