摘要
目的对自制的丹皮酚渗透泵片进行包衣膜处方工艺考察。方法将含2.5%乙基纤维素(EC)、10%邻苯二甲酸二丁酯(DBP)、10%聚乙二醇-4000(PEG-4000)的无水乙醇包衣液采用喷雾法制备成丹皮酚渗透泵片包衣膜,通过考察吸水量,观察释药前后的表面形态变化并进行包衣后的释放度测定,对包衣膜进行性质考察。结果丹皮酚渗透泵片包衣膜柔韧、致密、均匀,能保证适当的水分进入,并且释放度测定表明丹皮酚渗透泵片在12 h能实现很好的零级释放。结论将含2.5%EC、10%DBP、10%PEG-4000的无水乙醇包衣液采用喷雾法制备成的丹皮酚渗透泵片包衣膜性能良好,为丹皮酚渗透泵片包衣膜处方筛选和质量控制提供了一定的实验依据。
To review the tablet coating formulation process and the nature of selfmade Pae osmotic pump membrane. Methods By wa ter absorption investigation, observation of surface morphology before and after release, the determination of drug release rate and the con dition for the preparation of the membrance and its performance were examined. Results Coating material could contain 2.5 % EC, 10% DBP, 10% PEG4000 in anhydrous ethanol coating liquid ,which could prepare flexible, compact, uniform membrane, and this experiment succesfully prepared paeonol sustainedrelease tablets of zero order release. Conclusions Selfmade Pae osmotic pump membrane has good proton conductivity. This study provides a reference to establish the quality standard and coating film formulation for the paeonol os motic pumps.
出处
《安徽医药》
CAS
2013年第5期754-756,共3页
Anhui Medical and Pharmaceutical Journal
