摘要
目的制备司坦唑醇自微乳给药体系并建立其质量评价方法。方法以乳化剂OP-10、异丙醇和吐温-80制备司坦唑醇自微乳给药系统,考察其粒径分布、电动电势和稳定性。采用HPLC法测定司坦唑醇的含量。结果所得自微乳稳定性良好,平均粒径为33.32 nm,电动电势为4.35 mV。司坦唑醇HPLC分析的线性范围为0.639～3.195μg(R2=1);平均回收率为99.91%(RSD=0.05%)。结论该制剂制备工艺简便可行,质量稳定可控。
Objective To prepare the microemulsion delivery system of Stanozolol and to estabLish its quality evaluation. MethOds The microemulsion delivery system was prepared with OP-10 emulsifier,Tween-80 and isopropyl alcohol, and its size distribution,Zeta potential and stability were examined. The contents of Stanozolol were determined by HPLC. Results The microemulsion of Stanozolol was stable well. The average particle size and Zeta potential were 33.32 nm and 4.35mV, respectively. The linear range of Stanozolol was 0. 639 - 3. 195 μg（ R2 = 1 ）. The average recovery of Trenbolone Acetate was 99.91% （ RSD = 0.05 % ）. Conclusions The preparation technique of the microemulsion is simple and feasible, and its quality is stable and controllable.
出处
《安徽医药》
CAS
2013年第5期740-742,共3页
Anhui Medical and Pharmaceutical Journal
关键词
司坦唑醇
自微乳制备
质量评价
stanozolol
microemulsion preparation
quality evaluation
