摘要
目的:研究罗替戈汀透皮贴剂对离体豚鼠皮的透皮吸收情况,比较自制贴剂与国外已上市产品的离体透皮过程。方法:采用改进Franz扩散池,于实验开始后不同时间点取样,用HPLC法测定样品中罗替戈汀的浓度。结果:自制贴剂和国外贴剂的体外透皮稳态速率分别为9.210,8.796μg.cm-2.h-1,二者透皮速率无显著性差异。实验结束揭去贴片后,贴片及皮肤中均有少量的药物残留,约为药物总量的2%～4%。结论:自制罗替戈汀贴剂有良好的透皮性能,其豚鼠离体透皮吸收程度与国外同类品种相当。
OBJECTIVE To investigate the percutaneous absorption of rotigotine transdermal patch through guinea pig skins,and compare in vitro the penetration release of self-made patches with foreign products already in marlcet.METHODS Using a modified Franz diffusion cell,samples were collected at various time points after the start of test.The concentrations of rotigotine in the samples were measured by HPLC.RESULTS The steady penetration rates of rotigotine of self-made products and foreign products in vitro were 9.210 μg·cm-2·h-1,8.796 μg·cm-2·h-1,respectively.There was no significant difference among the permeation rates of two products.Rotigotine residues were detected in the patches and skins after the two sources of the patches were removed from the tested skins.The amount of rotigotine residues counted for 2%~4% of the total medicine in patches.CONCLUSION The self-made patches have good property of penetration,and the percutaneous absorption through guinea pig skins are similar to foreign products.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2013年第10期779-782,共4页
Chinese Journal of Hospital Pharmacy
关键词
罗替戈汀
透皮贴剂
经皮渗透
rotigotine
transdermal patch
percutaneous permeation
