摘要
目的探讨应用流式细胞检测技术测定特发性血小板减少性紫癜患者外周血中血小板相关免疫球蛋白水平及T淋巴细胞亚群变化情况。方法采用流式细胞仪检测我院25例特发性血小板减少性紫癜患者(观察组),对照组(正常健康者)25例,对两组患者外周血中血小板相关免疫球蛋白水平及T淋巴细胞亚群变化比较分析。结果观察组患者外周血中血小板相关免疫球蛋白水平均明显高于对照组(P<0.05);观察组患者的CD3+,CD3+CD4+亚群明显较对照组降低(P<0.05),而其CD3+CD8+亚群明显较对照组升高(P<0.05),且CD3+CD4+/CD3+CD8+比值显著降低(P<0.05)。结论特发性血小板减少性紫癜患者外周血中血小板相关免疫球蛋白水平明显增高,T淋巴细胞亚群变化明显,与该病免疫机制有关。
Objective To explore the changes of T lymphocyte subsets and clinical significance in patients with peripheral blood purpura by Flow cytometry. Methods 25 cases with idiopathic thrombocytopenic purpura of the observation group were used flow cytometry, in 25 cases of the control group （healthy people）,eompared the platelet in peripheral blood associated immunoglobulin levels and changes in T lymphocyte subsets of two groups. Results The platelet in peripheral blood associated immunoglobulin levels of the observation group was significantly higher than the control group （P 〈 0.05）, CD3＋CD4＋/CD3＋CD8＋ subsets of the observation group significantly decreased than the control group （P 〈 0.05）,and the CD3＋CD8＋ subsets significantly increased than the control group （P 〈 0.05）,the specific value of the CD3＋CD4＋/CD3＋CD8＋ was decreased significantly （P 〈 0.05）. Conclusion The platelet in peripheral blood associated immunoglobulin levels of patients with idiopathic thrombocytopenic purpura is increased significantly, changes of T lymphocyte subsets are obviously, there is a relationship with immune mechanism.
出处
《中国医药科学》
2013年第9期124-125,145,共3页
China Medicine And Pharmacy
