摘要
以N-2,9-二乙酰基鸟嘌呤和1,4-二乙酰氧基-2-氧杂丁烷为原料,经缩合反应制备阿昔洛韦有关物质2-[[2-(acetyl-amino)-6-oxo-1,6-dihydro-7H-purin-7-yl]methoxyl]ethylacetate(化合物2),化合物2经过水解反应可得到阿昔洛韦有关物质2-a-mino-7-[(2-hydroxyehoxy)methyl]-1,7-dihydro-6H-purin-6-one(化合物3)。
2-[ [ 2-（ acetylamino ）-6-oxo-1,6-dihydro-7 H-purin-7-yl ] methoxyl ] ethyl acetate （ compound 2 ） was synthesized by condensation reaction using N-2-acetyl-9-（2-acetoxyethoxymethyl） guanine and 1,4-di-acethoxy-2-oxabutene as raw materials. The compound 2 was hydrolysized to give 2-amino-7-[ （2-hydroxyehoxy ） methyl]- 1,7-dihydro -6 H-purin-6-one （ compound 3 ）.
出处
《精细与专用化学品》
CAS
2013年第5期37-39,共3页
Fine and Specialty Chemicals
