摘要
目的观察不同疗程安络化纤丸联合阿德福韦酯(ADV)治疗代偿期乙型肝炎肝硬化的临床疗效。方法将104例慢性乙型肝炎代偿期肝硬化患者随机分成3组,均服用ADV:A组38例,服用安络化纤丸1年;B组30例,服用安络化纤丸2年;C组(对照组)36例,只服用ADV。治疗前后检测患者肝功能、HBVDNA、HBV标志物、血清肝纤维化4项(透明质酸、Ⅲ型前胶原、Ⅳ型胶原和层粘连蛋白)以及门静脉内径、脾静脉内径和脾脏厚度。结果治疗2年后,A组肝功能复常率、HBVDNA阴转率和HBeAg阴转率分别为94.74%、52.63%和42.31%,B组分别为93.33%、53.33%和42.86%,C组分别91.67%、52.78%和44.00%,但3组间差异无统计学意义。3组间纤维化4项及超声检查3项指标下降幅度的差异均有统计学意义,B组下降幅度最大,C组下降幅度最小。结论安络化纤丸联合ADV有益于改善肝纤维化指标;治疗疗程越长,抗纤维化效果越明显。
Objective To investigate the efficacy of different courses of A nluohuaxian capsule combined with adefovir dipi- voxil （ADV） in treatment of hepatitis B-related compensated cirrhosis. Methods Totally 104 patients with hepatitis B-related com- pensated cirrhosis were randomized into 3 groups. In addition to the administration of ADV, group A （n=38） received Anluohuaxian capsule for 1 year, group B （n=30） received Anluohuaxian capsule for 2 years, and group C （the control group） （n=36） only received ADV. Liver function, HBV DNA, HBV markers, serum levels of hyaluronic acid （HA）, type m procollagen （PC m）, type IV collagen （IV-C） and laminin （LN）, the diameters of portal vein and splenic vein, and the thickness of spleen were detected before and after treatment. Results After 2 years of treatment, the rates of liver function normalization, HBV DNA negative conversion and HBeAg negative conversion were 94.74%, 52.63% and 42.31% in group A, 93.33%, 53.33% and 42.86% in group B, and 91.67%, 52.78% and 44.00% in group C, respectively, and no significant differences were found among the 3 groups. The decreases in the levels of HA, PC m, IV-c, LN, the diameters of portal vein and splenic vein and the thickness of spleen were the greatest in group B and the least in group C, and significant differences were found among the 3 groups. Conclusions A nluohuaxian capsule combined with ADV can help to improve liver fibrosis indicators. The longer the duration of combination therapy of A nluohuaxian capsule and ADV, the better anti-fibrosis efficacy will be.
出处
《传染病信息》
2013年第2期108-111,共4页
Infectious Disease Information
关键词
肝硬化
抗病毒药
乙型肝炎病毒
治疗结果
liver cirrhosis
antiviral agents
hepatitis B virus
treatment outcome
