摘要
目的:观察三维适形放射治疗(3 dimensional conformal radiotherapy,3DCRT)联合化疗治疗胰腺癌的临床疗效。方法:回顾分析我院自2006年1月至2011年6月收治的60例胰腺癌患者。治疗组28例,于化疗第1天行3DCRT,每周期第1、8、21、29天静滴吉西他滨(GEM)1000mg/m2,草酸铂130mg/m2,静脉滴注。对照组32例,给予每周期第1、8、21、29天静滴GEM 1 000mg/m2,草酸铂130mg/m2,静脉滴注。比较两组治疗完成情况、临床疗效、毒副反应及生存情况。结果:治疗组治疗完成率89.29%,对照组治疗完成率93.75%,两组在统计学上差异无显著性意义(P>0.05);两组总有效率分别为25.0%与3.1%(P<0.05)。两组毒副反应主要为血小板减少(28.6%,21.9%),白细胞下降(39.3%,31.3%),胃肠道反应(82.1%,75.0%)以及肝功能变化(10.7%,9.4%),两组毒副反应发生率比较,差异无统计学意义(P>0.05);治疗组与对照组在6个月生存率(82.1%,53.1%)、12个月生存率(46.4%,21.9%)及中位生存期(11.2个月,7.6个月)比较,差异具有统计学显著性意义(P<0.05)。结论:3DCRT+吉西他宾+草酸铂治疗胰腺癌疗效确切,可减轻临床症状。
Objective：To study the therapeutic effectiveness of three - dimensional conformal radiation therapy （3DCRT） combined with chemo -therapy to cancer of pancreas. Methods：We analyzed 60 cases with cancer of pancreas from Jan 2006 to June 2011,60 cases were randomly divided into 2 groups：28 cases in the experimental group given 3DCRT,gemcitabine and oxaliplatin,and 32 cases in control group given gemcitabine and oxaliplatin. Results：The completion rate of treatment were no significant statistics differences of 89.29% and 93.75% in 2 groups（P 〉 0.05 ）. The total effective rates were significant different of 25.0% and 3.1% （ P 〈 0.05 ）. The adverse effect were no significant differences（P 〉 0.05 ）, thrombopeny （ 28.6%, 21.9% ）, blood corpuscle to fall （ 39.3%, 31.3% ）, gastrointestinal react （ 82.1%, 75.0% ）, hepatic function （ 10.7%, 9.4% ）. There were significant differences of survival rate（P 〈0.05）, 6 months survival rate （82.1% ,53.1% ）, 12 months survival rate （46.4%, 21.9% ） and median survival（ 11.2 months ,7.6 months）. Concolusion ：3 DCRT ＋ gemcitabine ＋ oxaliplatin were ef- fective for panceatic cancer.
出处
《现代肿瘤医学》
CAS
2013年第5期1084-1086,共3页
Journal of Modern Oncology
关键词
胰腺癌
3DCRT
吉西他宾
草酸铂
pancreas cancer
3 dimensional conformal radiotherapy
gemcitabine
oxaliplatin
