摘要
miRNA是真核细胞中一类长约22nt的非编码小分子RNA,它们可通过碱基序列互补配对与靶mRNA分子结合并将后者降解,从而对靶基因实施转录后水平负调控,在生物发育调节及抗逆反应中发挥重要作用。miR164家族是植物特有的一类miRNA,其主要的靶基因是植物NAC家族转录因子。从miR164的特点、对NAC家族的调控、表达时序及组织分布特征和对环境及生物胁迫的响应,以及miR164及其靶基因的验证方法等方面,作一简要综述。
MicroRNAs （miRNAs） are a class of non-coding small RNA molecules of -22 nt in eukaryotic cells. They can complementarily combine with the mRNAs of target genes and cause their degradation, conducting post-transcriptionally negative regulation and thus playing important roles in a variety of biological growth/development processes and stress-resistance responses. The miR164 family is a group of plant-specific miRNAs, whose target genes mainly are the NAC transcriptional factor family. This paper presents a brief summary on the characteristics of the miR164 family, their regulation of NAC genes, their spatial-temporal expression and distribution and their responses to environmental or biological stress, as well as the methods of validation of miR164s and their target genes.
出处
《生命科学》
CSCD
2013年第5期532-538,共7页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(31071661)
高等学校博士学科点专项科研基金(20104404110020)
