摘要
目的:观察胰岛素注射联合口服格列齐特片治疗糖尿病肾病(DN)的临床疗效及不良反应。方法:选取62例T2DM合并DN患者,按治疗方案不同分为对照组,30例,仅以胰岛素注射;研究组,32例,胰岛素注射联合格列齐特口服。治疗12周后,分别比较两组的空腹血糖(FBG)、餐后2h血糖(PBG)、糖化血红蛋白(HbA1c)和肾功能指标及不良反应发生率差异。结果:与治疗前比较,治疗后两组FBG、PBG、HbA1c及肾功能指标(BUN、SCr、24h尿蛋白定量)均有下降(P<0.05);与对照组比较,研究组的上述指标下降程度更明显(P<0.05)。两组的低血糖、胃肠道反应及血细胞减少等发生率无差异(P>0.05)。结论:胰岛素注射联合格列齐特口服治疗DN的临床疗效显著且不良反应小。
Objective： To observe the curative effects and adverse reactions of insulin injection combination with gliclazide in the treatment of diabetic nephropathy （ DN ） .Method： A total of 62 patients with type 2 diabete mellitus （ T2DM ） and DN were taken prospective analyses and divided into two groups, control group （ 30 cases, received with insulin injection ） and research group （ 30 cases, received with insulin injection combined with gliclazide, 32 cases ）,according to therapeutic regimen.The therapeutic courses d the two groups were 12 weeks.The indexes d fasting blood glucose （ FBG ）, 2-hr plasma glucose （ PBG ）, glycolated hemoglobin （ HbAlc ） and renal function were compared between two groups.The incidence rates of side effects in two groups were observed and recorded.Result： Compared to pre-treatment, the indexes of FBG, PBG, HbAlc and renal function （ BUN, SCr and 24-hr m＇inary protein quantitative ） in pest-treatment were lower （ P〈0.05 ） .Compared to control group, the above indexes in research group were lower （ P〈0.05 ） .But the incidence rates of side effects in two groups were no different, such as hypoglycemia, gastrointestinal reaction, bemocytopenia （ P〉0.05 ）. Conclusion： The curative effect d insulin injection combination with gliclazide in the treatment of DN is perfect and no obvious side effect.
出处
《中国医学创新》
CAS
2013年第15期31-32,共2页
Medical Innovation of China
