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衣原体质粒的研究进展 被引量：2

Research progress on Chlamydia plasmid
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摘要 衣原体质粒是一个分子量约为7.5 kb,基因序列高度保守,非整合性的DNA分子,广泛存在于沙眼衣原体的各个血清型中,鼠衣原体和鹦鹉热衣原体也携带该质粒。近年来,人们发现衣原体质粒是一种毒力因子,可以导致小鼠输卵管积水。动物实验显示质粒缺失株可作为减毒活疫苗来预防衣原体感染所致的生殖道和眼睛的病变。不仅如此,衣原体质粒还是一种有效的基因操纵工具,可用于沙眼衣原体致病机制的研究。因此,开展对衣原体质粒的研究具有重要的意义。 Chlamydia plasmid is a 7.5 kb, highly conserved, non-integrative DNA molecule present in almost all strains of Chlamydia trachomatis, as well as Chlamydia muridarum and Chlamydia psittaci. Recently, Chlamydia plasmid has been considered to be a virulence factor which contributes to mouse oviduct hydrosalpinx. Studies in animal models indicate that plasmid-deficient Chlamydia strains function as live attenuated vaccines against genital and ocular Chlamydia infections. Nevertheless, Chlamydia plasmid is also a potential genetic manipulation tool for revealing Chlamydia trachomatis pathogenic mechanism. Therefore, research on Chlamydia plasmid is very meaningful.
作者 侯淑萍
机构地区 天津医科大学总医院皮肤科
出处 《微生物学通报》 CAS CSCD 北大核心 2013年第5期866-870,共5页 Microbiology China
关键词 衣原体质粒 毒力因子 减毒活疫苗 Chlamydia plasmid, Virulence factor, Live attenuated vaccines
分类号 R759 [医药卫生—皮肤病学与性病学]
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共引文献55

同被引文献15

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微生物学通报
2013年 第5期

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