摘要
目的分析探讨气管支气管异物患者继发肺部感染的病原菌分布和药物敏感性,为临床诊断、用药提供依据。方法采用回顾性分析方法,收集自2003-2010年气管支气管异物继发肺部感染患者113例痰液标本,进行细菌培养及药敏试验,使用SPSS15.0统计软件对其结果进行χ2检验分析。结果气管支气管异物继发肺感染的前3位病原菌分别为肺炎克雷伯菌、大肠埃希菌和金黄色葡萄球菌,其中金黄色葡萄球菌对万古霉素最敏感,敏感率为100.0%,对庆大霉素较为敏感,敏感率为72.3%,对氨苄西林的敏感率为18.2%;肺炎克雷伯菌对亚胺培南敏感率最高为100.0%,对头孢噻肟敏感率为61.1%,而对头孢唑林的敏感率仅为16.7%;大肠埃希菌对亚胺培南的敏感率为100.0%,对头孢曲松的敏感率为71.4%,而对氨苄西林敏感性最低,仅为14.3%,差异均有统计学意义(P<0.05)。结论金黄色葡萄球菌肺感染患者应用万古霉素效果最好,而肺炎克雷伯菌和大肠埃希菌感染患者则对亚胺培南比较敏感,说明万古霉素和亚胺培南依旧是治疗气管支气管异物继发肺部感染的最后手段。
OBJECTIVE To analyze the distribution and drug sensitivity of the species of pathogens causing secondary pulmonary infections in the patients with tracheobronchial foreign bodies so as to provide basis for clinical diagnosis and prescription. METHODS By means of the retrospective survey, totally 113 cases of sputum specimens were collected from patients with foreign bodies in the trachea and bronchi and the secondary pulmonary infections during 2003--2010. The bacterial culture and drug susceptibility testing were performed, and the chi- square test for the data was carried out by using statistical software SPSS15. 0. RESULTS The Klebsiella pneumoniae, Escherichia coli and Staphylococcus aureus were the top three species of pathogens causing the secondary pulmonary infections in the patients with tracheobronchial foreign bodies. The drug susceptibility rate of the S. aureus to vancomycin was 100.0%, 72.3% to gentamycin,and 18.2% to ampicillin; the drug susceptibility rate of the E. coli to imipenem was 100.0%, 61.1% to cefotaxime, and 16.7% to cephazoline; the drug resistance rate of the K. pneumoniae to imipenem was 100. 0%, 71. 4% to ceftriaxone, and 14. 3% to ampicillin, the difference was statistically significant（P〈0.05）. CONCLUSION The S. aureus is vancomycin-sensitive, and the K. pneumoniae and E. co2i are imipenem-sensitive, so vancomycin and imipenem remain the last resort for the treatment of secondary pulmonary infections in the patients with tracheobronchial foreign bodies.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第10期2484-2486,共3页
Chinese Journal of Nosocomiology
关键词
肺部感染
病原菌分布
药物敏感性
气管支气管
Pulmonary infection
Distribution of bacteria
Drug susceptibility
Tracheobronchial
