摘要
目的探讨克拉霉素联合头孢哌酮/舒巴坦治疗慢性阻塞性肺疾病(COPD)合并下呼吸道感染的疗效及安全性,为临床合理用药提供参考。方法 156例COPD合并下呼吸道感染患者随机分为治疗组和对照组,每组各78例;均给予止咳、化痰、吸氧、抗感染及维持水电解质酸碱平衡等常规综合治疗,对照组应用头孢哌酮/舒巴坦,治疗组应用克拉霉素联合头孢哌酮/舒巴坦,疗程2周,比较两组患者的临床疗效、肺功能改变及不良反应。结果治疗组的总有效率91.0%,显著高于对照组75.6%,差异有统计学意义(P<0.05);治疗后,两组患者的肺功能呼吸峰速(PEF)、第1秒用力呼气容积(FEV1)、FEV1占预计值的百分比及第1秒用力呼气容积占用力肺活量比值(FEV1/FVC)均较治疗前显著升高,差异有统计学意义(P<0.05),而治疗组的PEF、FEV1、FEV1/FVC显著高于对照组,差异有统计学意义(P<0.05);治疗组和对照组不良反应发生率分别为11.5%和9.0%,差异无统计学意义。结论克拉霉素联合头孢哌酮/舒巴坦治疗COPD合并下呼吸道感染具有协同作用,可控制临床症状,改善肺功能。
OBJECTIVE To explore the clinical efficacy and safety of clarithromycin combined with cefoperazone/ sulbactam in treatment of chronic obstructive pulmonary disease （COPD） complicated with lower respiratory tract infections so as to guide the reasonable clinical use of antibiotics. METHODS A total of 156 cases of COPD complicated with lower respiratory infection patients were randomly divided into the treatment group and the control group with 78 cases in each. All the patients were treated with low flow oxygen, antibiotics, cough and phlegm and maintaining water and electrolyte acid-base balance and other conventional treatment. The treatment group （N= 78） was given the clarithromycin and cefoperazone/sulbactam, and the control group （N = 78） was given the cefoperazone/sulbactam respectively. The clinical effect, change of lung function, and side effect were observed. RESULTS The total effective rate of the treatment group was 91.0%, significantly higher than 75.6%/%0 of the control group, the difference was statistically significant （P〈 0. 05）. After treatment, the peak of pulmonary function （PEF）, of the first second （FEV1）, and the ratio of （FEV1/FVC） in both group were significantly higher than those before the treatment, the difference was statistically significant （P〈0.05）, and these indicators in treatment group were increased more remarkably than those in the control group, the difference was statistically significant （P〈0.05）. The incidence rate of the side effect was 11.5% in the treatment group and 9.0% in the control group, the difference was not statistically significant. CONCLUSION The clarithromycin combined with cefoperazone/sulbactam has natural synergic effect on the treatment of COPD complicated with lower respiratory tract infections and can control the clinical symptoms and improve the lung function.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第10期2451-2453,共3页
Chinese Journal of Nosocomiology
关键词
慢性阻塞性肺疾病
克拉霉素
头孢哌酮
舒巴坦
Chronic obstructive pulmonary disease
Clarithromycin
Cefoperazone/sulbactam
