摘要
目的:探讨141例肝硬化患者血清肿瘤标志物水平变化的临床意义。方法:收治确诊为肝硬化患者141例,回顾性分析其AFP、CEA、CA19-9、CA125及临床资料情况。结果:肝硬化组与对照组比较,除AFP外其他差异均有统计学意义。肝硬化患者按Child-pugh分级后CEA、CA19-9、CA125各组间差异具有统计学意义。且CA19-9、CA125随分级的增高有逐渐升高的趋势,与Child-pugh分级相关的TBIL、ALB、PT各组间比较差异具有统计学意义。结论:肝硬化患者血清CEA水平明显升高,CA19-9、CA125可用评价肝细胞损伤,判断疾病进展。CA125是肝硬化失代偿期腹水与腹腔内感染的标志物。
Objective：To Investigate the clini- cal significance of levels of serum tumor markers in 141 cases of patients with liver cirrhosis. Methods： Retrospective analysis of AFP, CEA, CA19 - 9, CA125 and clinical datas was made in 141 cases of liver cirrho- sis in the Sixth People Hospital of Sheny- ang. Results： Cirrhosis compared with the control group, there were significant differ- ences in addition to AFP. CEA Grading of cirrhosis in patients with Child - pugh CEA, CA19 - 9, CA125 differences between groups were statistically significant And CA19-9,CA125 with graded increases had graduaJly increased, Child - pugh classification TBIL, ALB, PT were statistically signifi- cant among the groups. Conclusions： Serum CEA level increased significantly in Patients with cirrhosis. CA19 - 9 and CA125 can be used to evaluate liver cell injury and deter- mine disease progression. CA125 was the marker of ascites of liver cirrhosis and intra - abdominal infections.
