摘要
目的探讨肺隐球菌病的临床特征，提高该病的临床诊疗水平。方法分析临床确诊肺隐球菌病住院患者的临床资料。结果32例肺隐球菌病患者中，非免疫缺陷患者17例，免疫缺陷患者15例；最常见的临床症状为咳嗽（18例，56．3％）、咳痰（10例，31．3％）、胸痛（9例，28．1％）。影像学特征主要以孤立的单发结节（18例，56．3%）与多发结节（12例，37．5％）多见，根据结节影的大小进行分类，以10～50mm的结节影最为常见（19例，59．4％）。本组18例孤立性结节病例中11例发生在右肺中、下叶，并且病变局限。疗效：治愈21例（65．6％），好转7例（21．9％），恶化2例（6．3％），死亡1例（3．1％），不能评价1例（3．1％）。结论肺隐球菌病多发于中年男性，可罹患于免疫功能正常与免疫缺陷人群，临床表现和影像学表现缺乏特异性，确诊依靠病理组织学活检，治疗包括手术切除和抗真菌药物治疗。
Objective To discuss the clinical features of pulmonary cryptococcosis and improve the clinical diagnosis and treatment level. Methods The clinical data of hospitalized patients with pulmonary cryptococcosis were analyzed. Results In 32 cases of pulmonary cryptococcosis, non-immunodeficient patients were 17 cases and immunodeficient patients were 15 cases. The most common clinical symptoms were cough （18 cases,56.3%）,expectoration （ten cases, 31.3%）, and chest pain （nine cases, 28.1%）. Imaging features were mainly isolated solitary nodules （18 cases, 56.3 %） and multiple nodules （12 cases, 37.5%）. According to the nodule size,10-50 mm nodules were the most common （19 cases,59.4%）. In 18 cases of solitary nodules, 11 cases occurred in the right lung, lower lobe, and lesions were limited. Curative effect.. 21 cases were cured （65.6%）, seven cases were improved （21.9%）, two cases were deteriorated （6.3%）, one case had death （3.1%）, and one case could not be evaluated （3.1%）. Conclusions Pulmonary cryptococcosis is more common in middle-aged men, available in an immunocompetent and immunocompromised population. Clinical and imaging manifestations are lack of specificity,diagnosis depends on pathological biopsy, treatment includes operation excision and antifungal agents in pulmonary cryptococcosis.
出处
《国际呼吸杂志》
2013年第10期735-738,共4页
International Journal of Respiration
关键词
肺隐球菌病
影像学表现
抗真菌药物
Pulmonary cryptococcosis
Imaging manifestations
Antifungal agents
