摘要
目的了解四川省黑水县人群血清利什曼原虫特异抗体阳性率。方法在四川省黑水县近年有内脏利什曼病病例报告的乡村采集人群血清．采用间接酶联免疫吸附试验检测利什曼原虫特异抗体。计算人群血清阳性率，统计不同年龄、职业组的阳性率，各组阳性率的比较采用r检验。结果共采集397份血清．抗体阳性者48人。阳性率为12．09％。色尔古乡、龙坝乡、维古乡、洛多乡的人群血清抗体阳性率依次为13．74％（18／131）、11．11％（9／81）、12．82％（11／107）和10．28％（10／78），各乡人群阳性率差异无统计学意义（X2=0．78，P〉0．05）。1～5、6-10、11，15、16～20和21岁以上各年龄组人群抗体阳性率分别为23．08％（3／13）、11．54％（6／52）、11．56％（26／225）、0（0／6）和12．87％（13／101），不同年龄组阳性率差异有统计学意义（X2=8．06，P〈0．05），以1-5岁年龄组最高（23．08％）。男、女性阳性率为12．21％（26／213）、11．96％（22／184），性别差异无统计学意义（X2=0．005，P〉0．05）。散居儿童、学生、教师及农民的阳性率依次为14.29％（3，21）、11．72％（32／273）、6．38％（3／47）和17．86％（10／56），职业间差异无统计学意义（r=3．05，P〉0．05）。结论四川省黑水县人群血清利什曼原虫特异抗体阳性率较高．应加强内脏利什曼病的防治工作。
Objective To investigate the positive rate of the specific antibody of human Leishmania infec- tion in serum of people in Heishui County of Sichuan Province, China. Methods The serum samples were col- lected from different townships where visceral leishmaniasis cases had been reported in recent years. ELISA was employed to test the specific antibody of the serum from residents. Seroprevalence of population was calculated, the positive rates in different age groups and different occupation groups were compared with of test. Results Among the 397 serum samples, 48 were found to be positive of antibody against Leishmania by ELISA with a serum positive rate of 12.09%. The serum positive rate of Serergu, Longba, Weigu, Luoduo was 13.74% （18/131 ）, 11.11% （ 9/81 ）, 12.82% （ 11/107 ） and 10.28% （ 10/78 ） respectively with no significant difference in serum positive rate at different townships （X2=0.78,P〉0.05）. The serum positive rate of 1-5, 6-10, 11-15, 16-20 and above 21 age group was 23.08%（3/13）, 11.54%（6/52）, 11.56%（26/225）, 0（0/6） and 12.87%（13/101）, there were significant difference with serum positive rate of antibody against Leishmania in different age group with the highest positive rate 23.08% in 1-5 age group （X2=8.06,P〈0.05） . The serum positive rate of male and female was 12.21% （26/ 213）,11.96% （22/184） with no significant difference （X2=0.005,P〉0.05）. The serum positive rate of scattered children, student, teacher and other nonagricultural worker, farmer was 14.29% （3/21 ）, 11.72% （32/273）, 6.38% （3/47） and 17.86%（10/56） with no significant difference （X2=3.05 ,P〉0.05）. Conclusion The results indicated that the positive rate of the specific antibody against human Leishmania infection in serum is high in population of Heishui County. It is necessary to strengthen Kala-azar prevention and treatment.
出处
《国际医学寄生虫病杂志》
CAS
2013年第3期149-151,175,共4页
International JOurnal of Medical Parasitic Diseases
关键词
内脏利什曼病
利什曼原虫感染
血清学调查
黑水县
Visceral leishmaniasis
Leishmania infection
Serological investigation
Heishui County
