摘要
目的:比较和评估两种宫颈癌筛查方法的应用价值。方法:选取进行宫颈癌检查并有活检结果的451个病例,均为宫颈刷取材、液基方法同时制两张片,一张进行巴氏染色用于常规细胞学TBS诊断,另一张经Feulgen染色用于细胞DNA定量分析检测。临床活检取材均在阴道镜指导下进行。结果:以活检结果作为金标准,451例中共有宫颈癌1例,CINⅢ/原位癌3例,3例CINⅡ及15例CINⅠ,其余均为慢性宫颈炎。以活检结果≥CINⅡ作为宫颈癌前病变的阳性标准,采用细胞DNA定量分析检测的敏感性和特异性分别为100.00%与95.50%,而常规细胞学检测的敏感性和特异性分别为42.86%与99.01%。同一个标本同时采用两种方法联合检测,敏感性可提高到100.00%。结论:细胞DNA定量分析技术可与常规细胞学联合开展应用在宫颈癌筛查中。
Objective： To compare and evaluate the application value of two methods for cervical cancer screening. Methods： 451 women were reviewed from the people who screened from March 2011 to March 2013. The cytology samples were taken by cervix brush and prepared for 2 slides ： one was read by cytologist and the other was tested by DNA image cytometer. The biopsy was taken with direction of colposcopy. Results： 451 biopsy results had been proved, including 1 cancer cases, 3 CINIII/CIS, 3 CIN lI and 15 CIN I . The sensitivity and specificity of DNA image cytometry were 100. 00% and 95.50% , the cytology of both of them was 42. 86% and 99. 01% respective- ly. The sensitivity could be increased to 100% by combination of two methods. Conclusion： DNA image cytometry can be used in cervical cancer screening combined with cytology.
出处
《中国妇幼保健》
CAS
北大核心
2013年第14期2304-2306,共3页
Maternal and Child Health Care of China
基金
贵州省科学技术厅课题〔黔科合中药字(2011)LKZ7007号〕
