摘要
目的 探讨炎性细胞因子IL 6、TNFα和其拮抗因子sTNFR水平的变化及其在急性胰腺炎 (AP)发生、发展和转归中的作用。方法 采用ELISA双抗体夹心法检测了轻、重 2组共 41例AP患者发病后第 1、5、14天外周血IL 6和可溶性肿瘤坏死因子受体 (sTNFR)水平的变化。结果 轻症组 2 2例患者在发病第 5天后逐渐恢复 ,重症组 19例中12例在发病后 5～ 7天病情渐趋好转。两组患者在发病后第 1、5、14天的sTNFR均明显升高 (P <0 .0 0 1) ,且重症组明显高于轻症组 (P <0 .0 1) ,但随着病情好转有逐渐下降趋势。IL 6重症组第 1天时显著性升高 (40 .38pg/ml,对照组为12 .41pg/ml,二者比较 ,P <0 .0 0 1) ,然后逐渐下降至正常。上述两指标均在发病第 1天达峰值 ,然后逐渐下降 ,与AP严重程度呈正相关 (P <0 .0 5 )。结论 血清IL 6。
HT6”,5”] [WT5”BZ] [WT5”HZ]Objective [WT5”BZ]To study the variety and the action of inflammatory cytokines and the relevant anti inflammatory factors in acute pancreatitis (AP). [WT5”HZ]Methods [WT5”BZ]The authors observed the change of peripheral blood IL 6 and sTNFR in 41 patients with mild and severe AP in two groups on 1, 5, 14d after acute attack by ELISA. [WT5”HZ]Results [WT5”BZ]All cases recovered gradually in mild group ( n =22) after five days. Twelve patients improved gradually in severe group ( n =19) after 5-7 days. The level of sTNFR increased markedly in 2 groups at 1, 5, 14d( P <0.001), and that of the severe group was markedly higher decreased gradually ( P <0.01). The level of IL 6 increased apparently only in severe group on 1d, 40.38 pg/ml∶12.4 pg/ml, ( P <0.001). The levels of IL 6 and sTNFR correlated respectively with severity of AP. [WT5”HZ]Conclusion [WT5”BZ]These results show that peripheral blood IL 6 and TNFα are useful index to supervise the severity and conversion and final results of AP. [HT6,5”] [WT5”HZ]
出处
《中国普外基础与临床杂志》
CAS
2000年第5期313-314,共2页
Chinese Journal of Bases and Clinics In General Surgery
关键词
急性胰腺炎
肿瘤坏死因子Α
白细胞介素-6
STNFR
Acute pancreatitis Tumor necrosis factor α Interleukin 6 Soluble tumor necrosis factor receptor
