摘要
目的 研究糖尿病 (diabetesmellitus ,DM )患者血红蛋白晚期糖基化终末产物 (hemoglobin ad vancedglycosylationendproducts ,Hb AGE)与糖尿病视网膜病变 (diabeticretinopathy ,DR)的关系。 方法 采用竞争性ELISA法检测 12 5例并发或未并发DR的Ⅱ型DM患者的Hb AGE含量 ,并与 5 0例正常对照者比较。 结果 DM患者Hb AGE比正常对照者平均增加 6 5 % ;并发DR者Hb AGE显著高于无DR患者 ;空腹血糖 (fastingplasmaglucoseFPG)水平与Hb AGE含量及DR发生率无直接相关性 ,血压 (BP)、HbA1c及血脂水平与Hb AGE含量和DR发生率有关 (P <0 .0 5 ,或P <0 .0 1)。多因素分析显示DR严重度与Hb AGE关系更为密切 (偏相关系数 =0 .6 0 4,P <0 .0 0 1)。 结论 DM控制与体内血红蛋白晚期糖基化终末产物(hemoglobin advancedglycosylationendproducs ,Hb AGE)含量改变有关 ,AGE大量形成与DR发生和发展有关。
Objective To study relationship between hemoglobin-AGE(Hb-AGE)levels and diabetic retinopathy(DR) in diabetics. Methods Hb-AGE content of 125 type 2 diabetic patients with or without DR was measured by competitive ELISA technique and compared with that of 50 normal controls. Results Hb-AGE level in type 2 diabetic patients was 65% higher than that in normal individuals(P<0.01),and Hb-AGE level in the patients with DR was significantly higher than that in those without DR(P<0.05).It was found that fasting plasma glucose(FPG)level was not directly correlated with Hb-AGE levels and developement of DR,but HbA1c,plasma lipid and blood pressure were related to the both(P<0.05 or P< 0.01). Multivariate analysis showed that there was closer relationship between seriousness degree of DR and Hb-AGE(partial correlation coefficient was 0.604,P<0.001). Conclusion Diabetic control is related to alterations in vivo Hb-AGE,which may contribute to occurrence and developement of DR in type 2 diabetes mellitus.
出处
《中华眼底病杂志》
CAS
CSCD
北大核心
2000年第3期147-149,共3页
Chinese Journal of Ocular Fundus Diseases
关键词
Ⅱ型糖尿病
视网膜病变
血红蛋白类
Hb-AGE
Diabetes mellitus
Non-insullin-dependent
Retinal disease/etiology
Hemoglobin/metabolism
