摘要
目的了解昌平区医院2011-2012年血培养病原菌分布、构成比及其耐药性，为临床合理用药提供依据。方法用Whonet5．6软件对2011～2012年6331份血培养标本中阳性标本的病原菌分布及耐药情况进行回顾性分析。结果6331份血培养标本中检出病原菌336株，革兰氏阴性杆菌、革兰氏阳性球菌及真菌分别占63．4％（213／336），35．7％（120／336）和0．9％（3／336）。G^-菌以大肠埃希氏菌、肺炎克雷伯菌、铜绿假单胞菌等为主。G^＋球菌中，以表皮葡萄球菌、粪肠球菌、人葡萄球菌、金黄色葡萄球菌等为主。真菌以白色假丝酵母菌为主。美洛培南对大肠埃希氏菌和肺炎克雷伯菌100％敏感，利奈唑胺、万古霉素、替加环素对阳性菌100％敏感，其它抗生素均有不同程度的耐药。结论血培养分离出的病原菌耐药率不断增强，应重视血培养标本检测及致病菌耐药性分析，应根据药敏试验结果及耐药趋势合理应用抗菌药物。
Objective To investigate the distribution and drug resistance of pathogenic bacteria of Changping Hospital in blood samples from 2011 to 2012. Methods Results of identification and drug sensitivity tests of pathogenic bacteria isolated from positive blood culture specimens of 6 331 blood samples during 2011 and 2012 were retrospectively analyzed by whonet 5.6 software. Results 366 strains of pathogenic bacteria were isolated frorh 6 331 cases of blood samples. Detection rates of Gram negative bacilli,Gram positive coccus and fungi were 63.4% （213/336） ,35.7 % （120/336） and 0.9% （3/336） ,respectively. Most Gram negative bacilli were Escherichia coli, Klebsiellar pneumonia and Pseudomonas aeruginosa. Most Gram positive coccui were Staphylococcus epidermidis , Entercoccus f aecalis , Staphylococcus hominis , Staphylococcus aureus. Fungi were Candida albicans. Meropenem against Escherichia coli,Klebsiella pneumoniae effect of good, Linezolid, Vancomycin and Tigecycline remained highly sensitive to the gram positive bacteria. Conclusion Bacterial resistance of pathogenic bacteria in blood samples is still on the rise. More attention should be paid for the detection and drug resistance analysis of pathogenic bacteria in blood samples,and antibacterials should be rationally used according to the results of drug sensitivity tests and the tendency of drug resistance variationl.
出处
《现代检验医学杂志》
CAS
2013年第2期154-156,共3页
Journal of Modern Laboratory Medicine
关键词
血培养
病原菌
细菌耐药性
blood culture pathogen
bacterial resistance
