摘要
采用溶剂辅助研磨法制备了阿折地平-马来酸复合物,应用XRD,DSC,IR,Raman,THz,ssNMR等手段对复合物进行表征,以探讨阿折地平与马来酸之间作用力的类型;采用溶解度方法推导和计算了二者在溶液中形成的热力学公式和参数;采用高效液相(HPLC)法测定了阿折地平的含量.在苯辅助研磨的条件下,阿折地平与马来酸以2∶1的物质的量比形成了新的复合物.热力学分析表明二者结合的强度较高,结合常数达105数量级.
The complex built upon azelnidipine grinding method and was characterized by powder and maleic acid was synthesized by using solvent-assisted X-ray diffraction （PXRD）,differential scanning calorim- etry （DSC）,infrared （IR） and Raman spectrum, solid-state nuclear magnetic resonance （ssNMR）,and ter- ahertz （THz） spectroscopy. The formation thermodynamics of the azelnidipine-maleie acid complex were extensively investigated by solubility method. The concentrations of azelnidipine were determined by HLPC method. New azelnidipine-maleic acid complex was formed at a molar ratio of 2 ~ I by toluene-assisted co- grinding. The interactions between azelnidipine and maleic acid were discussed. Thermodynamics analysis indicated that the complex force between them was intense;the complex constants K were evaluated to be 10s orders of magnitude.
出处
《河北师范大学学报（自然科学版）》
CAS
北大核心
2013年第3期280-286,共7页
Journal of Hebei Normal University：Natural Science
基金
国家自然科学基金(81202504)
河北省科技支撑项目(12276402D)
河北省教育厅重点项目(2009148)
关键词
阿折地平
复合物
太赫兹谱
固态核磁
热力学
azelnidipine
complex
THz spectra
solid state NMR
thermodynamics
